Literature DB >> 21889825

Natural products: an evolving role in future drug discovery.

Bhuwan B Mishra1, Vinod K Tiwari.   

Abstract

The therapeutic areas of infectious diseases and oncology have benefited from abundant scaffold diversity in natural products, able to interact with many specific targets within the cell and indeed for many years have been source or inspiration for the majority of FDA approved drugs. The present review describes natural products (NPs), semi-synthetic NPs and NP-derived compounds that have undergone clinical evaluation or registration from 2005 to 2010 by disease area i.e. infectious (bacterial, fungal, parasitic and viral), immunological, cardiovascular, neurological, inflammatory and related diseases and oncology.
Copyright © 2011 Elsevier Masson SAS. All rights reserved.

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Year:  2011        PMID： 21889825     DOI： 10.1016/j.ejmech.2011.07.057

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  161 in total

Review 1.  Neuroprotective Effect of Natural Products on Peripheral Nerve Degeneration: A Systematic Review.

Authors:  Heitor G Araújo-Filho; Lucindo J Quintans-Júnior; André S Barreto; Jackson R G S Almeida; Rosana S S Barreto; Jullyana S S Quintans
Journal:  Neurochem Res       Date:  2015-12-08       Impact factor: 3.996

Review 2.  Strategies for the Optimization of Natural Leads to Anticancer Drugs or Drug Candidates.

Authors:  Zhiyan Xiao; Susan L Morris-Natschke; Kuo-Hsiung Lee
Journal:  Med Res Rev       Date:  2015-09-11       Impact factor: 12.944

3.  In vitro and in vivo efficacy of novel flavonoid dimers against cutaneous leishmaniasis.

Authors:  Iris L K Wong; Kin-Fai Chan; Yun-Fu Chen; Zhao-Rong Lun; Tak Hang Chan; Larry M C Chow
Journal:  Antimicrob Agents Chemother       Date:  2014-03-31       Impact factor: 5.191

Review 4.  The re-emergence of natural products for drug discovery in the genomics era.

Authors:  Alan L Harvey; RuAngelie Edrada-Ebel; Ronald J Quinn
Journal:  Nat Rev Drug Discov       Date:  2015-01-23       Impact factor: 84.694

Review 5.  Oxidative Cyclization in Natural Product Biosynthesis.

Authors:  Man-Cheng Tang; Yi Zou; Kenji Watanabe; Christopher T Walsh; Yi Tang
Journal:  Chem Rev       Date:  2016-12-12       Impact factor: 60.622

6.  Genetic origins of lactase persistence and the spread of pastoralism in Africa.

Authors:  Alessia Ranciaro; Michael C Campbell; Jibril B Hirbo; Wen-Ya Ko; Alain Froment; Paolo Anagnostou; Maritha J Kotze; Muntaser Ibrahim; Thomas Nyambo; Sabah A Omar; Sarah A Tishkoff
Journal:  Am J Hum Genet       Date:  2014-03-13       Impact factor: 11.025

7.  Bioactive compounds from Vitex leptobotrys.

Authors:  Wenhui Pan; Kanglun Liu; Yifu Guan; Ghee Teng Tan; Nguyen Van Hung; Nguyen Manh Cuong; D Doel Soejarto; John M Pezzuto; Harry H S Fong; Hongjie Zhang
Journal:  J Nat Prod       Date:  2014-01-09       Impact factor: 4.050

8.  Ginseng extract reduces tacrolimus-induced oxidative stress by modulating autophagy in pancreatic beta cells.

Authors:  Sun Woo Lim; Long Jin; Kang Luo; Jian Jin; Chul Woo Yang
Journal:  Lab Invest       Date:  2017-07-31       Impact factor: 5.662

Review 9.  Counting on natural products for drug design.

Authors:  Tiago Rodrigues; Daniel Reker; Petra Schneider; Gisbert Schneider
Journal:  Nat Chem       Date:  2016-04-25       Impact factor: 24.427

10.  Antimicrobial Activity of Selected Polyphenols and Capsaicinoids Identified in Pepper (Capsicum annuum L.) and Their Possible Mode of Interaction.

Authors:  Meriem Mokhtar; Giovanna Ginestra; Fatma Youcefi; Angela Filocamo; Carlo Bisignano; Ali Riazi
Journal:  Curr Microbiol       Date:  2017-07-18       Impact factor: 2.188
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