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Literature DB >> 21887123

GONADAL HORMONE INDEPENDENT SEX DIFFERENCES IN STEROIDOGENIC FACTOR 1 KNOCKOUT MICE BRAIN.

Tomaž Büdefeld¹, Stuart A Tobet, Gregor Majdič.

Abstract

Sex differences in brain morphology have been described in a number of species including humans. Gonadal hormones were shown to provide a major influence on brain sexual differentiation more than 50 years ago. A growing number of studies is providing evidence for roles of genetic factors, in particular sex chromosome complement, on brain sexual differentiation in mammals. In this review, hormone-independent brain sexual differentiation, with the emphasis on mice with a disruption of the SF-1 gene (SF-1 knockout, SF-1 KO) are discussed.

Entities: Chemical Disease Gene Species

Year: 2010 PMID： 21887123 PMCID： PMC3163895

Source DB: PubMed Journal: Slov Vet Zb ISSN： 1580-4003 Impact factor: 0.749

19 in total

Review 1. Neuropeptides, food intake and body weight regulation: a hypothalamic focus.

Authors: J J G Hillebrand; D de Wied; R A H Adan
Journal: Peptides Date: 2002-12 Impact factor: 3.750

2. Organizing action of prenatally administered testosterone propionate on the tissues mediating mating behavior in the female guinea pig.

Authors: C H PHOENIX; R W GOY; A A GERALL; W C YOUNG
Journal: Endocrinology Date: 1959-09 Impact factor: 4.736

Review 3. Development of the ventromedial nucleus of the hypothalamus.

Authors: Kristy M McClellan; Keith L Parker; Stuart Tobet
Journal: Front Neuroendocrinol Date: 2006-04-17 Impact factor: 8.606

4. A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation.

Authors: X Luo; Y Ikeda; K L Parker
Journal: Cell Date: 1994-05-20 Impact factor: 41.582

5. Knockout mice lacking steroidogenic factor 1 are a novel genetic model of hypothalamic obesity.

Authors: Gregor Majdic; Morag Young; Elise Gomez-Sanchez; Paul Anderson; Lidia S Szczepaniak; Robert L Dobbins; J Denis McGarry; Keith L Parker
Journal: Endocrinology Date: 2002-02 Impact factor: 4.736

6. Chronic fasting-induced changes of neuropeptide Y immunoreactivity in the lateral septum of intact and ovariectomized female rats.

Authors: Eva G Kovács; Ferenc Szalay; Bence Rácz; Katalin Halasy
Journal: Brain Res Date: 2007-03-28 Impact factor: 3.252

GONADAL HORMONE INDEPENDENT SEX DIFFERENCES IN STEROIDOGENIC FACTOR 1 KNOCKOUT MICE BRAIN.

Review 1. Neuropeptides, food intake and body weight regulation: a hypothalamic focus.

2. Organizing action of prenatally administered testosterone propionate on the tissues mediating mating behavior in the female guinea pig.

Review 3. Development of the ventromedial nucleus of the hypothalamus.

4. A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation.

5. Knockout mice lacking steroidogenic factor 1 are a novel genetic model of hypothalamic obesity.

6. Chronic fasting-induced changes of neuropeptide Y immunoreactivity in the lateral septum of intact and ovariectomized female rats.

7. Sex differences in brain developing in the presence or absence of gonads.

Review 8. What does the "four core genotypes" mouse model tell us about sex differences in the brain and other tissues?

9. A model system for study of sex chromosome effects on sexually dimorphic neural and behavioral traits.

10. Sex chromosome complement and gonadal sex influence aggressive and parental behaviors in mice.

1. Gonadal hormone-independent sex differences in GABA_A receptor activation in rat embryonic hypothalamic neurons.

2. Sex differences in mood disorders: perspectives from humans and rodent models.