Literature DB >> 12535710

Neuropeptides, food intake and body weight regulation: a hypothalamic focus.

J J G Hillebrand1, D de Wied, R A H Adan.   

Abstract

Energy homeostasis is controlled by a complex neuroendocrine system consisting of peripheral signals like leptin and central signals, in particular, neuropeptides. Several neuropeptides with anorexigenic (POMC, CART, and CRH) as well as orexigenic (NPY, AgRP, and MCH) actions are involved in this complex (partly redundant) controlling system. Starvation as well as overfeeding lead to changes in expression levels of these neuropeptides, which act downstream of leptin, resulting in a physiological response. In this review the role of several anorexigenic and orexigenic (hypothalamic) neuropeptides on food intake and body weight regulation is summarized.

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Year:  2002        PMID： 12535710     DOI： 10.1016/s0196-9781(02)00269-3

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  56 in total

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