OBJECTIVE: To assess whether there is an increased prevalence of joint hypermobility in patients with vesico-ureteric reflux (VUR). MATERIALS AND METHODS: We studied 50 patients with primary VUR and matched controls drawn from a reference population. Joint mobility was assessed using the Bulbena hypermobility score. RESULTS: We identified significantly more patients with VUR with generalized joint hypermobility than controls (24% vs 6.7%, P= 0.007). CONCLUSION: Our findings confirm our clinical observation of an increased rate of joint hypermobility in patients with VUR. We speculate that an altered composition of the connective tissue may contribute to the severity of the (pre-existing) VUR phenotype.
OBJECTIVE: To assess whether there is an increased prevalence of joint hypermobility in patients with vesico-ureteric reflux (VUR). MATERIALS AND METHODS: We studied 50 patients with primary VUR and matched controls drawn from a reference population. Joint mobility was assessed using the Bulbena hypermobility score. RESULTS: We identified significantly more patients with VUR with generalized joint hypermobility than controls (24% vs 6.7%, P= 0.007). CONCLUSION: Our findings confirm our clinical observation of an increased rate of joint hypermobility in patients with VUR. We speculate that an altered composition of the connective tissue may contribute to the severity of the (pre-existing) VUR phenotype.
Authors: Rasheed A Gbadegesin; Patrick D Brophy; Adebowale Adeyemo; Gentzon Hall; Indra R Gupta; David Hains; Bartlomeij Bartkowiak; C Egla Rabinovich; Settara Chandrasekharappa; Alison Homstad; Katherine Westreich; Guanghong Wu; Yutao Liu; Danniele Holanda; Jason Clarke; Peter Lavin; Angelica Selim; Sara Miller; John S Wiener; Sherry S Ross; John Foreman; Charles Rotimi; Michelle P Winn Journal: J Am Soc Nephrol Date: 2013-04-25 Impact factor: 10.121