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Literature DB >> 27139901

Vesicoureteral reflux and the extracellular matrix connection.

Fatima Tokhmafshan¹, Patrick D Brophy², Rasheed A Gbadegesin^3,4, Indra R Gupta^5,6.

Abstract

Primary vesicoureteral reflux (VUR) is a common pediatric condition due to a developmental defect in the ureterovesical junction. The prevalence of VUR among individuals with connective tissue disorders, as well as the importance of the ureter and bladder wall musculature for the anti-reflux mechanism, suggest that defects in the extracellular matrix (ECM) within the ureterovesical junction may result in VUR. This review will discuss the function of the smooth muscle and its supporting ECM microenvironment with respect to VUR, and explore the association of VUR with mutations in ECM-related genes.

Entities: Chemical Disease Gene Species

Keywords: Collagen; Cutis laxa; Ehlers–Danlos syndrome; Elastin; Joint hypermobility; Marfan syndrome; Tenascin-XB; Ureterovesical junction; Vesicoureteral reflux; Williams syndrome

Mesh：

Year: 2016 PMID： 27139901 PMCID： PMC5376290 DOI： 10.1007/s00467-016-3386-5

Source DB: PubMed Journal: Pediatr Nephrol ISSN： 0931-041X Impact factor: 3.714

167 in total

Review 1. Elastic proteins: biological roles and mechanical properties.

Authors: John Gosline; Margo Lillie; Emily Carrington; Paul Guerette; Christine Ortlepp; Ken Savage
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2002-02-28 Impact factor: 6.237

Review 2. Joint hypermobility syndromes: the pathophysiologic role of tenascin-X gene defects.

Authors: Manon C Zweers; Alan J Hakim; Rodney Grahame; Joost Schalkwijk
Journal: Arthritis Rheum Date: 2004-09

3. Embryology and anatomy of the vesicoureteric junction with special reference to the etiology of vesicoureteral reflux.

Authors: Christian Radmayr; Christian Schwentner; Andreas Lunacek; Anastasios Karatzas; Josef Oswald
Journal: Ther Adv Urol Date: 2009-12

Vesicoureteral reflux and the extracellular matrix connection.

Review 1. Elastic proteins: biological roles and mechanical properties.

Review 2. Joint hypermobility syndromes: the pathophysiologic role of tenascin-X gene defects.

3. Embryology and anatomy of the vesicoureteric junction with special reference to the etiology of vesicoureteral reflux.

4. Hypermobility in two Dutch school populations.

5. A view on the anatomy of the ureterovesical junction.

6. Abnormal copper metabolism and deficient lysyl oxidase activity in a heritable connective tissue disorder.

7. Endoscopic treatment with dextranomer-hyaluronic acid for vesicoureteral reflux: histological findings.

8. Prevalence estimation of Williams syndrome.

9. Hypermobility: prevalence and features in a Swedish population.

10. Tenascin-X induces cell detachment through p38 mitogen-activated protein kinase activation.

Review 1. Tenascin-X, Congenital Adrenal Hyperplasia, and the CAH-X Syndrome.

2. Congenital Anomalies of the Kidney and Urinary Tract: A Clinical Review.

Review 3. Physiopathology of vesico-ureteral reflux.

4. Tenascin-X-Discovery and Early Research.