BACKGROUND AND OBJECTIVES: To identify clinicopathologic variables that could predict pathologic tumor response to neoadjuvant chemotherapy for patients with locally advanced gastric cancer. METHODS: The study enrolled 108 patients who underwent neoadjuvant chemotherapy followed by surgery between July 2004 and December 2010. Tumor responses to neoadjuvant chemotherapy were assessed in terms of tumor regression. Statistical analyses were performed to identify factors associated with pathologic tumor response. RESULTS: Tumor regression was found in 22.2% (24/108) patients, patients with tumor regression observed better overall survival as compared to that of patients without tumor regression. Univariate and multivariate analyses observed that both tumor differentiation and tumor size were independent predictors of tumor regression. CONCLUSIONS: This study suggests that both tumor differentiation and tumor size is the most important clinical predicator of pathologic tumor response, it may be of benefit in the selection of treatment options in locally advanced gastric cancer.
BACKGROUND AND OBJECTIVES: To identify clinicopathologic variables that could predict pathologic tumor response to neoadjuvant chemotherapy for patients with locally advanced gastric cancer. METHODS: The study enrolled 108 patients who underwent neoadjuvant chemotherapy followed by surgery between July 2004 and December 2010. Tumor responses to neoadjuvant chemotherapy were assessed in terms of tumor regression. Statistical analyses were performed to identify factors associated with pathologic tumor response. RESULTS:Tumor regression was found in 22.2% (24/108) patients, patients with tumor regression observed better overall survival as compared to that of patients without tumor regression. Univariate and multivariate analyses observed that both tumor differentiation and tumor size were independent predictors of tumor regression. CONCLUSIONS: This study suggests that both tumor differentiation and tumor size is the most important clinical predicator of pathologic tumor response, it may be of benefit in the selection of treatment options in locally advanced gastric cancer.
Authors: Fernando Mingol; Javier Gallego; Albina Orduña; Amparo Martinez-Blasco; Javier Sola-Vera; Pedro Moya; Miguel Angel Morcillo; Juan Antonio Ruiz; Rafael Calpena; Francisco-Javier Lacueva Journal: BMC Surg Date: 2015-05-22 Impact factor: 2.102
Authors: Rong Yue Teng; Ji Chun Zhou; Zi Nong Jiang; Chao Yang Xu; Zi Duo Li; Qing Chuan Wang; Chen Pu Xu; Ju Feng Guo; Jian Guo Shen; Lin Bo Wang Journal: Onco Targets Ther Date: 2013-09-24 Impact factor: 4.147
Authors: Jian Guo Shen; Jun Shen; Rong Yue Teng; Lin Bo Wang; Wen He Zhao; Qin Chuan Wang Journal: Pathol Oncol Res Date: 2021-03-30 Impact factor: 3.201