Literature DB >> 2188027

Production of monoclonal antibody to human esophageal cancer cell line.

M Naito1, M Imamura, R Kannagi, T Tobe.   

Abstract

The immunization of Balb/C mice with esophageal cell line KYSE-50 established from poorly-differentiated esophageal squamous cell carcinoma, resulted in obtaining the monoclonal antibody KYMN-28-5. This monoclonal antibody is of the IgM class and recognizes a carbohydrate antigen contained in glycoproteins with molecular weights of 53 and 56K, and in neutral glycolipids extracted from teratomas. Tissue staining revealed that this monoclonal antibody reacts strongly with malignant tumors but only weakly, or not at all, with normal tissues, apart from squamous epithelial tissue. KYMN-28-5 is thus a useful tumor marker which will improved the accuracy of serological diagnosing squamous cell carcinoma when combined with the measurement of SCC antigen.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 2188027     DOI： 10.1007/bf02470765

Source DB:  PubMed          Journal:  Jpn J Surg        ISSN： 0047-1909


  13 in total

1.  Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

Authors:  H Towbin; T Staehelin; J Gordon
Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205

2.  [Usefulness of SCC-antigen for diagnosis and monitoring recurrence and effectiveness of therapies of squamous cell carcinoma of the lung].

Authors:  N Mino; A Iio; M Ata; K Murase; M Kataoka; H Ito; M Ishine; M Kawamura; K Hamamoto
Journal:  Kaku Igaku       Date:  1987-02

3.  Tumor-associated antigen, TA-4, in the monitoring of the effects of therapy for squamous cell carcinoma of the uterine cervix. Serial determinations and tissue localization.

Authors:  T Maruo; K Shibata; A Kimura; M Hoshina; M Mochizuki
Journal:  Cancer       Date:  1985-07-15       Impact factor: 6.860

4.  [Squamous cell carcinoma related antigen in serum of the patients with esophageal carcinoma].

Authors:  M Kitamura; H Matsuda; H Matsuura; H Kai; H Ageo; K Sugimachi
Journal:  Nihon Geka Gakkai Zasshi       Date:  1985-11

5.  Sialosyllactotetraosylceramide, a novel ganglioside antigen detected in human carcinomas by a monoclonal antibody.

Authors:  O Nilsson; J E Månsson; L Lindholm; J Holmgren; L Svennerholm
Journal:  FEBS Lett       Date:  1985-03-25       Impact factor: 4.124

6.  Immunohistochemical demonstration of tumor antigen TA-4 in gynecologic tumors.

Authors:  G Ueda; Y Inoue; M Yamasaki; M Inoue; Y Tanaka; K Hiramatsu; J Saito; T Nishino; Y Abe
Journal:  Int J Gynecol Pathol       Date:  1984       Impact factor: 2.762

7.  Specific antigen in serum of patients with colon carcinoma.

Authors:  H Koprowski; M Herlyn; Z Steplewski; H F Sears
Journal:  Science       Date:  1981-04-03       Impact factor: 47.728

8.  Radioimmunoassay for tumor antigen of human cervical squamous cell carcinoma.

Authors:  H Kato; T Torigoe
Journal:  Cancer       Date:  1977-10       Impact factor: 6.860

9.  Monoclonal antibodies against gastrointestinal tumour-associated antigens isolated as monosialogangliosides.

Authors:  L Lindholm; J Holmgren; L Svennerholm; P Fredman; O Nilsson; B Persson; H Myrvold; T Lagergård
Journal:  Int Arch Allergy Appl Immunol       Date:  1983

10.  Significance of squamous cell carcinoma (SCC)-related antigens in cutaneous SCC. A preliminary report.

Authors:  H Yagi; K Danno; Y Maruguchi; M Yamamoto; S Imamura
Journal:  Arch Dermatol       Date:  1987-07
View more
  2 in total

1.  The effect of radioimmunotherapy using murine monoclonal antibody KIS1 on esophageal squamous cell carcinoma-bearing nude mice.

Authors:  T Fujii; H Yamana; Y Toh; U Toh; H Fujita; K Shirouzu; M Morimatsu
Journal:  Surg Today       Date:  1997       Impact factor: 2.549

2.  Characterization of a monoclonal antibody reactive with a glycolipid antigen expressed by tumorigenic and certain immortalized, non-tumorigenic rat esophageal epithelial cell lines.

Authors:  X Wan; R J Jamasbi; G D Stoner
Journal:  Cancer Immunol Immunother       Date:  1993       Impact factor: 6.968
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.