OBJECTIVE: The purpose of this study was to evaluate (18)F-FDG-PET, PET/CT, and CT in the diagnosis of benign or malignant solitary pulmonary nodules (SPNs) in areas with a high incidence of TB. METHODS: Ninety-six patients with a SPN smaller than 30 mm were studied prospectively. PET/CT images were obtained 60 min after intravenous injection of (18)F-FDG. The data obtained for each patient were analyzed and the accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated and compared using χ(2) test. RESULTS: The sensitivity, specificity, accuracy, PPV, and NPV in the diagnosis of SPN were 86.7, 72.2, 81.3, 83.9, and 76.5%, respectively, for CT and 88.3, 61.1, 79.1, 79.1, and 75.9%, respectively, for PET. Tuberculosis was responsible for 57.1% (8/14) of false-positives on PET. The sensitivity, specificity, accuracy, PPV, and NPV in the diagnosis of SPN were 96.7, 75.7, 88.5, 88.1, and 94.4% for PET/CT. The accuracy of PET/CT was higher than that of either CT or PET alone (P < 0.05). CONCLUSION: PET has a high false-positive rate in areas with a high incidence of TB; combined PET and CT (PET/CT) can improve the diagnostic accuracy in the differentiation of an SPN.
OBJECTIVE: The purpose of this study was to evaluate (18)F-FDG-PET, PET/CT, and CT in the diagnosis of benign or malignant solitary pulmonary nodules (SPNs) in areas with a high incidence of TB. METHODS: Ninety-six patients with a SPN smaller than 30 mm were studied prospectively. PET/CT images were obtained 60 min after intravenous injection of (18)F-FDG. The data obtained for each patient were analyzed and the accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated and compared using χ(2) test. RESULTS: The sensitivity, specificity, accuracy, PPV, and NPV in the diagnosis of SPN were 86.7, 72.2, 81.3, 83.9, and 76.5%, respectively, for CT and 88.3, 61.1, 79.1, 79.1, and 75.9%, respectively, for PET. Tuberculosis was responsible for 57.1% (8/14) of false-positives on PET. The sensitivity, specificity, accuracy, PPV, and NPV in the diagnosis of SPN were 96.7, 75.7, 88.5, 88.1, and 94.4% for PET/CT. The accuracy of PET/CT was higher than that of either CT or PET alone (P < 0.05). CONCLUSION: PET has a high false-positive rate in areas with a high incidence of TB; combined PET and CT (PET/CT) can improve the diagnostic accuracy in the differentiation of an SPN.
Authors: Ji Young Choo; Ki Yeol Lee; Mi-Young Kim; Eun-Young Kang; Yu Whan Oh; Seung Hwa Lee; Bo Kyung Seo; Bo Kyung Je Journal: Balkan Med J Date: 2014-09-01 Impact factor: 2.021
Authors: M Beth McCarville; Catherine Billups; Jianrong Wu; Robert Kaufman; Sue Kaste; Jamie Coleman; Susan Sharp; Helen Nadel; Martin Charron; Henrique Lederman; Steven Don; Stephen Shochat; Najat C Daw; Barry Shulkin Journal: AJR Am J Roentgenol Date: 2013-12 Impact factor: 3.959
Authors: Stephen A Deppen; Jeffrey D Blume; Clark D Kensinger; Ashley M Morgan; Melinda C Aldrich; Pierre P Massion; Ronald C Walker; Melissa L McPheeters; Joe B Putnam; Eric L Grogan Journal: JAMA Date: 2014-09-24 Impact factor: 56.272