BACKGROUND: This study was undertaken to assess the value of neutrophils CD11b, CD64, and CD62L for the early diagnosis of neonatal infection. METHODS: Eighty-four neonates who were followed up for a suspected neonatal infection were included in this study. They were assigned into an infection group (n=49) and a non-infection group (n=35). Healthy neonates served as controls (n=35). A full sepsis screening was performed and neutrophil and monocyte expressions of CD11b, CD64 and CD62L were determined by flow cytometry. RESULTS: The expressions of CD64 and CD11b were significantly enhanced in the infection group compared to the non-infective group and the controls. CONCLUSIONS: CD64 expression on neutrophils and monocytes is a useful diagnostic marker for the early diagnosis of neonatal infection. Combination of CD64, CD11b and C reactive protein further enhances the sensitivity of the expression and its negative predictive value.
BACKGROUND: This study was undertaken to assess the value of neutrophils CD11b, CD64, and CD62L for the early diagnosis of neonatal infection. METHODS: Eighty-four neonates who were followed up for a suspected neonatal infection were included in this study. They were assigned into an infection group (n=49) and a non-infection group (n=35). Healthy neonates served as controls (n=35). A full sepsis screening was performed and neutrophil and monocyte expressions of CD11b, CD64 and CD62L were determined by flow cytometry. RESULTS: The expressions of CD64 and CD11b were significantly enhanced in the infection group compared to the non-infective group and the controls. CONCLUSIONS:CD64 expression on neutrophils and monocytes is a useful diagnostic marker for the early diagnosis of neonatal infection. Combination of CD64, CD11b and C reactive protein further enhances the sensitivity of the expression and its negative predictive value.
Authors: Stephanie Lynema; Daniel Marmer; Eric S Hall; Jareen Meinzen-Derr; Paul S Kingma Journal: Am J Perinatol Date: 2014-07-31 Impact factor: 1.862
Authors: Hassan O Eliwan; William R G Watson; Irene Regan; Brian Philbin; Fiona M O'Hare; Tammy Strickland; Amanda O'Neill; Michelle O'Rourke; Alfonso Blanco; Martina Healy; Beatrice Nolan; Owen Smith; Eleanor J Molloy Journal: Front Pediatr Date: 2019-09-27 Impact factor: 3.418