OBJECTIVE: To examine associations between autonomic nervous system and adrenocortical reactivity to laboratory stressors and buccal cell telomere length (BTL) in children. METHODS: The study sample comprised 78 children, aged 5 to 6 years, from a longitudinal cohort study of kindergarten social hierarchies, biologic responses to adversity, and child health. Buccal cell samples and reactivity measures were collected in the spring of the kindergarten year. BTL was measured by real-time polymerase chain reaction, as the telomere-to-single-copy gene ratio. Parents provided demographic information; parents and teachers reported children's internalizing and externalizing behavior problems. Components of children's autonomic (heart rate, respiratory sinus arrhythmia [RSA], and preejection period [PEP]) and adrenocortical (salivary cortisol) responses were monitored during standardized laboratory challenges. We examined relationships between reactivity, internalizing and externalizing behaviors, and BTL, adjusted for age, race, and sex. RESULTS: Heart rate and cortisol reactivity were inversely related to BTL, PEP was positively related to BTL, and RSA was unrelated to BTL. Internalizing behaviors were also inversely related to BTL (standardized β = -0.33, p = .004). Split at the median of reactivity parameters, children with high sympathetic activation (decreasing PEP), and parasympathetic withdrawal (decreasing RSA) did not differ with regard to BTL. However, children with both this profile and high cortisol reactivity (n = 12) had significantly shorter BTL (0.80 versus 1.00; χ² = 7.6, p = .006), compared with other children. CONCLUSIONS: The combination of autonomic and adrenocortical reactivity was associated with shorter BTL in children. These data suggest that psychophysiological processes may influence, and that BTL may be a useful marker of, early biologic aging.
OBJECTIVE: To examine associations between autonomic nervous system and adrenocortical reactivity to laboratory stressors and buccal cell telomere length (BTL) in children. METHODS: The study sample comprised 78 children, aged 5 to 6 years, from a longitudinal cohort study of kindergarten social hierarchies, biologic responses to adversity, and child health. Buccal cell samples and reactivity measures were collected in the spring of the kindergarten year. BTL was measured by real-time polymerase chain reaction, as the telomere-to-single-copy gene ratio. Parents provided demographic information; parents and teachers reported children's internalizing and externalizing behavior problems. Components of children's autonomic (heart rate, respiratory sinus arrhythmia [RSA], and preejection period [PEP]) and adrenocortical (salivary cortisol) responses were monitored during standardized laboratory challenges. We examined relationships between reactivity, internalizing and externalizing behaviors, and BTL, adjusted for age, race, and sex. RESULTS: Heart rate and cortisol reactivity were inversely related to BTL, PEP was positively related to BTL, and RSA was unrelated to BTL. Internalizing behaviors were also inversely related to BTL (standardized β = -0.33, p = .004). Split at the median of reactivity parameters, children with high sympathetic activation (decreasing PEP), and parasympathetic withdrawal (decreasing RSA) did not differ with regard to BTL. However, children with both this profile and high cortisol reactivity (n = 12) had significantly shorter BTL (0.80 versus 1.00; χ² = 7.6, p = .006), compared with other children. CONCLUSIONS: The combination of autonomic and adrenocortical reactivity was associated with shorter BTL in children. These data suggest that psychophysiological processes may influence, and that BTL may be a useful marker of, early biologic aging.
Authors: Abbey Alkon; Lauren H Goldstein; Nancy Smider; Marilyn J Essex; David J Kupfer; W Thomas Boyce Journal: Dev Psychobiol Date: 2003-01 Impact factor: 3.038
Authors: Marilyn J Essex; W Thomas Boyce; Lauren Heim Goldstein; Jeffrey M Armstrong; Helena C Kraemer; David J Kupfer Journal: J Am Acad Child Adolesc Psychiatry Date: 2002-05 Impact factor: 8.829
Authors: Scott Brouilette; Ravi K Singh; John R Thompson; Alison H Goodall; Nilesh J Samani Journal: Arterioscler Thromb Vasc Biol Date: 2003-03-20 Impact factor: 8.311
Authors: Samuel J Ridout; Kathryn K Ridout; Hung-Teh Kao; Linda L Carpenter; Noah S Philip; Audrey R Tyrka; Lawrence H Price Journal: Adv Psychosom Med Date: 2015-03-30
Authors: Judith E Carroll; Tara L Gruenewald; Shelley E Taylor; Denise Janicki-Deverts; Karen A Matthews; Teresa E Seeman Journal: Proc Natl Acad Sci U S A Date: 2013-09-23 Impact factor: 11.205
Authors: Daniel Lindqvist; Elissa S Epel; Synthia H Mellon; Brenda W Penninx; Dóra Révész; Josine E Verhoeven; Victor I Reus; Jue Lin; Laura Mahan; Christina M Hough; Rebecca Rosser; F Saverio Bersani; Elizabeth H Blackburn; Owen M Wolkowitz Journal: Neurosci Biobehav Rev Date: 2015-05-18 Impact factor: 8.989
Authors: Katherine P Theall; Zoë H Brett; Elizabeth A Shirtcliff; Erin C Dunn; Stacy S Drury Journal: Soc Sci Med Date: 2013-02-27 Impact factor: 4.634
Authors: Christopher W Jones; Kyle C Esteves; Sarah A O Gray; Tegan N Clarke; Keegan Callerame; Katherine P Theall; Stacy S Drury Journal: Psychoneuroendocrinology Date: 2019-03-22 Impact factor: 4.905
Authors: Stacy S Drury; Brittany R Howell; Christopher Jones; Kyle Esteves; Elyse Morin; Reid Schlesinger; Jerrold S Meyer; Kate Baker; Mar M Sanchez Journal: Dev Psychopathol Date: 2017-12
Authors: Stacy S Drury; Emily Mabile; Zoë H Brett; Kyle Esteves; Edward Jones; Elizabeth A Shirtcliff; Katherine P Theall Journal: Pediatrics Date: 2014-06-16 Impact factor: 7.124