Literature DB >> 2187295

Involvement of an initiation factor and protein phosphorylation in translational control of GCN4 mRNA.

A G Hinnebusch1.   

Abstract

Regulation of the GCN4 gene of Saccharomyces cerevisiae is one of the best-documented instances of gene-specific translational control in an eukaryote. Upstream open reading frames (uORFs) in GCN4 mRNA modulate the flow of scanning ribosomes to the GCN4 start codon according to the availability of amino acids. Recent results suggest that sequences at the termination codons of the uORFs, a general initiation factor, and a protein kinase all make important contributions to the proper functioning of this interesting translational-control element.

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Year:  1990        PMID： 2187295     DOI： 10.1016/0968-0004(90)90215-w

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  46 in total

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Authors:  R Stripecke; M W Hentze
Journal:  Nucleic Acids Res       Date:  1992-11-11       Impact factor: 16.971

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4.  Ovule development: identification of stage-specific and tissue-specific cDNAs.

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5.  In vitro suppression as a tool for the investigation of translation initiation.

Authors:  V A Karginov; S V Mamaev; S M Hecht
Journal:  Nucleic Acids Res       Date:  1997-10-01       Impact factor: 16.971

6.  The immunosuppressant FK506 inhibits amino acid import in Saccharomyces cerevisiae.

Authors:  J Heitman; A Koller; J Kunz; R Henriquez; A Schmidt; N R Movva; M N Hall
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7.  The homeobox gene ATK1 of Arabidopsis thaliana is expressed in the shoot apex of the seedling and in flowers and inflorescence stems of mature plants.

Authors:  J Dockx; N Quaedvlieg; G Keultjes; P Kock; P Weisbeek; S Smeekens
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8.  The REG2 gene of Saccharomyces cerevisiae encodes a type 1 protein phosphatase-binding protein that functions with Reg1p and the Snf1 protein kinase to regulate growth.

Authors:  D L Frederick; K Tatchell
Journal:  Mol Cell Biol       Date:  1996-06       Impact factor: 4.272

9.  Mutation creates an open reading frame within the 5' untranslated region of macaque erythrocyte carbonic anhydrase (CA) I mRNA that suppresses CA I expression and supports the scanning model for translation.

Authors:  N C Bergenhem; P J Venta; P J Hopkins; H J Kim; R E Tashian
Journal:  Proc Natl Acad Sci U S A       Date:  1992-09-15       Impact factor: 11.205

10.  The homeobox gene ATH1 of Arabidopsis is derepressed in the photomorphogenic mutants cop1 and det1.

Authors:  N Quaedvlieg; J Dockx; F Rook; P Weisbeek; S Smeekens
Journal:  Plant Cell       Date:  1995-01       Impact factor: 11.277
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