Literature DB >> 21872367

Discovery of a new class of HMG-CoA reductase inhibitor from Polyalthia longifolia as potential lipid lowering agent.

Koneni V Sashidhara1, Suriya P Singh, Anuj Srivastava, Anju Puri, Yashpal S Chhonker, Rabi S Bhatta, Priyanka Shah, Mohammad Imran Siddiqi.   

Abstract

Bioassay guided fractionation of the ethanolic extract of Polyalthia longifolia var. pendula, led to the discovery of the clerodane diterpene, 16α-hydroxycleroda-3, 13 (14) Z-dien-15, 16-olide (1), as a new structural class of HMG-CoA reductase inhibitor. Importantly, the in vivo effects of 1 corroborated well with its molecular docking analysis and also with its hamster plasma pharmacokinetics.
Copyright © 2011 Elsevier Masson SAS. All rights reserved.

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Year:  2011        PMID： 21872367     DOI： 10.1016/j.ejmech.2011.08.012

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  11 in total

Review 1.  Clerodane diterpenes: sources, structures, and biological activities.

Authors:  Rongtao Li; Susan L Morris-Natschke; Kuo-Hsiung Lee
Journal:  Nat Prod Rep       Date:  2016-07-18       Impact factor: 13.423

2.  Antidyslipidemic effect and antioxidant activity of anthraquinone derivatives from Rheum emodi rhizomes in dyslipidemic rats.

Authors:  Sunil K Mishra; Shashi Tiwari; Atul Shrivastava; Shishir Srivastava; Goutam K Boudh; Shivendra K Chourasia; Upma Chaturvedi; Snober S Mir; Anil K Saxena; Gitika Bhatia; Vijai Lakshmi
Journal:  J Nat Med       Date:  2013-12-17       Impact factor: 2.343

3.  Pharmacological evaluation of the efficacy of Dysoxylum binectariferum stem bark and its active constituent rohitukine in regulation of dyslipidemia in rats.

Authors:  Sunil K Mishra; Shashi Tiwari; Shishir Shrivastava; Ravi Sonkar; Vaibhav Mishra; Sunil K Nigam; Anil K Saxena; Gitika Bhatia; Snober S Mir
Journal:  J Nat Med       Date:  2014-03-28       Impact factor: 2.343

4.  Pharmacokinetics, metabolism, bioavailability, tissue distribution and excretion studies of 16α-hydroxycleroda-3, 13(14) Z -dien-15, 16-olide-a novel HMG-CoA reductase inhibitor.

Authors:  Tulsankar Sachin Laxman; Santosh Kumar Puttrevu; Rajesh Pradhan; Anjali Mishra; Sarvesh Verma; Yashpal S Chhonker; Swarnim Srivastava; Suriya P Singh; Koneni V Sashidhara; Rabi Sankar Bhatta
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2018-06-06       Impact factor: 3.000

5.  Induction of mitochondrial dysfunction and oxidative stress in Leishmania donovani by orally active clerodane diterpene.

Authors:  Manoj Kathuria; Arindam Bhattacharjee; Koneni V Sashidhara; Suriya Pratap Singh; Kalyan Mitra
Journal:  Antimicrob Agents Chemother       Date:  2014-07-28       Impact factor: 5.191

6.  Bioactivity guided fractionation and hypolipidemic property of a novel HMG-CoA reductase inhibitor from Ficus virens Ait.

Authors:  Danish Iqbal; M Salman Khan; Mohd Sajid Khan; Saheem Ahmad; Md Sarfaraj Hussain; Mohd Ali
Journal:  Lipids Health Dis       Date:  2015-03-04       Impact factor: 3.876

7.  Influence of extraction methods of bay leaves (Syzygium polyanthum) on antioxidant and HMG-CoA Reductase inhibitory activity.

Authors:  Lanny Hartanti; Stefania Maureen Kasih Yonas; Josianne Jacqlyn Mustamu; Sumi Wijaya; Henry Kurnia Setiawan; Lisa Soegianto
Journal:  Heliyon       Date:  2019-04-09

8.  Clerodane Diterpenoids from an Edible Plant Justicia insularis: Discovery, Cytotoxicity, and Apoptosis Induction in Human Ovarian Cancer Cells.

Authors:  Idowu E Fadayomi; Okiemute R Johnson-Ajinwo; Elisabete Pires; James McCullagh; Tim D W Claridge; Nicholas R Forsyth; Wen-Wu Li
Journal:  Molecules       Date:  2021-09-30       Impact factor: 4.411

9.  7-Acetoxyhorminone from Salvia multicaulis Vahl. as Promising Inhibitor of 3-Hydroxy-3-methylglutaryl Coenzyme A (HMG-CoA) Reductase.

Authors:  Serkan Yigitkan; Abdulselam Ertas; Ramin Ekhteiari Salmas; Mehmet Firat; Ilkay Erdogan Orhan
Journal:  Pharmaceuticals (Basel)       Date:  2022-02-04

10.  16-Hydroxycleroda-3,13-dien-15,16-olide Induces Apoptosis in Human Bladder Cancer Cells through Cell Cycle Arrest, Mitochondria ROS Overproduction, and Inactivation of EGFR-Related Signalling Pathways.

Authors:  Yu-Chi Chen; Po-Yu Wang; Bu-Miin Huang; Yu-Jen Chen; Wei-Chang Lee; Yung-Chia Chen
Journal:  Molecules       Date:  2020-08-30       Impact factor: 4.411
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