| Literature DB >> 21871542 |
Siddig Ibrahim Abdelwahab1, Loiy Elsir Ahmed Hassan, Hasnah Mohd Sirat, Sakina M Ahmed Yagi, Waleed S Koko, Syam Mohan, Manal Mohamed Elhassan Taha, Syahida Ahmad, Cheah Shiau Chuen, Putri Narrima, Mohd Mustafa Rais, A Hamid A Hadi.
Abstract
The in vivo and in vitro mechanistic anti-inflammatory actions of cucurbitacin E (CE) (Citrullus lanatus var. citroides) were examined. The results showed that LPS/INF-γ increased NO production in RAW264.7 macrophages, whereas L-NAME and CE curtailed it. CE did not reveal any cytotoxicity on RAW264.7 and WRL-68 cells. CE inhibited both COX enzymes with more selectivity toward COX-2. Intraperitoneal injection of CE significantly suppressed carrageenan-induced rat's paw edema. ORAC and FRAP assays showed that CE is not a potent ROS scavenger. It could be concluded that CE is potentially useful in treating inflammation through the inhibition of COX and RNS but not ROS.Entities:
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Year: 2011 PMID： 21871542 DOI： 10.1016/j.fitote.2011.08.002
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882