RATIONALE: Ambient particulate matter concentrations have been positively associated with urinary leukotriene E(4) (LTE(4)) levels and albuterol usage in children with asthma but interactions with environmental tobacco smoke (ETS) exposure have not been demonstrated despite obvious exposure to both pollutants in an urban setting. OBJECTIVES: To assess the health effects of concurrent ETS and ambient particulate matter exposure in children with asthma. METHODS: Albuterol usage and LTE(4) levels were monitored in 82 urban schoolchildren with asthma over three consecutive fall to spring school periods. Concentrations of morning maximum ambient particulate matter <2.5 μm in aerodynamic diameter (mmPM(2.5)) and urine cotinine levels were also measured daily. MEASUREMENTS AND MAIN RESULTS: Albuterol usage and LTE(4) were related to mmPM(2.5) concentrations on days when urine cotinine levels were low (<10 ng/ml/mg creatinine); on these days, mean albuterol usage and LTE(4) increased up to 5 or 6% per 10 μg/m(3) increase in mmPM(2.5). In contrast, no significant relationship was observed when cotinine was high, although mean albuterol usage and LTE(4) levels were greater in this case. Model fits for LTE(4) levels as a function of mmPM(2.5) concentrations were improved when mmPM(2.5) concentrations were logged, suggesting a nonlinear dose-response relationship between particulate matter exposure concentrations and airway mediators of asthma, for which the relationship tends to flatten at higher concentrations. CONCLUSIONS: This study suggests that ETS modifies the acute effects of low-level ambient PM(2.5) exposure on childhood asthma. This negative interaction, the smaller effect of particulate matter exposure in children exposed to higher ETS, may be related to a nonlinear dose-response relationship between asthma mediators and particulate exposures.
RATIONALE: Ambient particulate matter concentrations have been positively associated with urinary leukotriene E(4) (LTE(4)) levels and albuterol usage in children with asthma but interactions with environmental tobacco smoke (ETS) exposure have not been demonstrated despite obvious exposure to both pollutants in an urban setting. OBJECTIVES: To assess the health effects of concurrent ETS and ambient particulate matter exposure in children with asthma. METHODS:Albuterol usage and LTE(4) levels were monitored in 82 urban schoolchildren with asthma over three consecutive fall to spring school periods. Concentrations of morning maximum ambient particulate matter <2.5 μm in aerodynamic diameter (mmPM(2.5)) and urine cotinine levels were also measured daily. MEASUREMENTS AND MAIN RESULTS:Albuterol usage and LTE(4) were related to mmPM(2.5) concentrations on days when urine cotinine levels were low (<10 ng/ml/mg creatinine); on these days, mean albuterol usage and LTE(4) increased up to 5 or 6% per 10 μg/m(3) increase in mmPM(2.5). In contrast, no significant relationship was observed when cotinine was high, although mean albuterol usage and LTE(4) levels were greater in this case. Model fits for LTE(4) levels as a function of mmPM(2.5) concentrations were improved when mmPM(2.5) concentrations were logged, suggesting a nonlinear dose-response relationship between particulate matter exposure concentrations and airway mediators of asthma, for which the relationship tends to flatten at higher concentrations. CONCLUSIONS: This study suggests that ETS modifies the acute effects of low-level ambient PM(2.5) exposure on childhood asthma. This negative interaction, the smaller effect of particulate matter exposure in children exposed to higher ETS, may be related to a nonlinear dose-response relationship between asthma mediators and particulate exposures.
Authors: C Arden Pope; Richard T Burnett; Daniel Krewski; Michael Jerrett; Yuanli Shi; Eugenia E Calle; Michael J Thun Journal: Circulation Date: 2009-08-31 Impact factor: 29.690
Authors: Lance A Wallace; Herman Mitchell; George T O'Connor; Lucas Neas; Morton Lippmann; Meyer Kattan; Jane Koenig; James W Stout; Ben J Vaughn; Dennis Wallace; Michelle Walter; Ken Adams; Lee-Jane Sally Liu Journal: Environ Health Perspect Date: 2003-07 Impact factor: 9.031
Authors: Pamela R Wood; Jordan C Kampschmidt; Peter H Dube; Marianna P Cagle; Paola Chaparro; Norma S Ketchum; Thirumalai R Kannan; Harjinder Singh; Jay I Peters; Joel B Baseman; Edward G Brooks Journal: Ann Allergy Asthma Immunol Date: 2017-06-19 Impact factor: 6.347
Authors: Andrea M Coverstone; Leonard B Bacharier; Bradley S Wilson; Anne M Fitzpatrick; William Gerald Teague; Wanda Phipatanakul; Sally E Wenzel; Benjamin M Gaston; Eugene R Bleecker; Wendy C Moore; Sima Ramratnam; Nizar N Jarjour; Ngoc P Ly; John V Fahy; David T Mauger; Kenneth B Schechtman; Huiqing Yin-DeClue; Jonathan S Boomer; Mario Castro Journal: Pediatr Pulmonol Date: 2019-08-19
Authors: Kelly J Brunst; Marco Sanchez-Guerra; Yueh-Hsiu Mathilda Chiu; Ander Wilson; Brent A Coull; Itai Kloog; Joel Schwartz; Kasey J Brennan; Michelle Bosquet Enlow; Robert O Wright; Andrea A Baccarelli; Rosalind J Wright Journal: Environ Int Date: 2017-12-15 Impact factor: 9.621
Authors: Nadya Y Rivera Rivera; Marcela Tamayo-Ortiz; Adriana Mercado García; Allan C Just; Itai Kloog; Martha Maria Téllez-Rojo; Robert O Wright; Rosalind J Wright; Maria José Rosa Journal: Environ Res Date: 2020-10-22 Impact factor: 6.498
Authors: Nathan Rabinovitch; Meaghan J Jones; Nicole Gladish; Anna V Faino; Matthew Strand; Alexander M Morin; Julie MacIsaac; David T S Lin; Paul R Reynolds; Amrit Singh; Erwin W Gelfand; Michael S Kobor; Christopher Carlsten Journal: Epigenetics Date: 2020-07-12 Impact factor: 4.528
Authors: Arunima Kohli; Marco A Garcia; Rachel L Miller; Christina Maher; Olivier Humblet; S Katharine Hammond; Kari Nadeau Journal: Clin Epigenetics Date: 2012-09-25 Impact factor: 6.551