| Literature DB >> 21868221 |
Nico Ueberschaar1, Basile Le Sage Tchize Ndejouong, Ling Ding, Armin Maier, Heinz-Herbert Fiebig, Christian Hertweck.
Abstract
Three unusual alkyhydrazide natural products, named hydrazidomycin A (1), B (2) and C (3), were isolated from the chloroform extract of a Streptomycesatratus culture, and their structures were elucidated by MS and NMR techniques. Hydrazidomycins A-C exhibited moderate to strong cytotoxic activities in a panel of 42 cell lines, with hydrazidomycin A being the most potent compound (mean IC(50)=0.37 μM).Entities:
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Year: 2011 PMID： 21868221 DOI： 10.1016/j.bmcl.2011.07.108
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823