OBJECTIVE: To establish how cause of death for live-born preterm infants (24-31 weeks gestation) has changed in a single large UK population over 2 decades. STUDY DESIGN: This was an interrogation of a population-based survey of >680, 000 live births (between 1988 and 2008) for deaths in the first postnatal year. We collected cause of death grouped into major etiologies: respiratory, infection, malformation, necrotizing enterocolitis (NEC), and other. Data were analyzed in three 7-year epochs and 2 gestational groups (<27 and 28-31 weeks). Numbers, rates per 1000 live births, and proportional contributions to each epoch were analyzed. RESULTS: A total of 1504 deaths occurred. The infants who died had a median gestational age of 26 weeks (IQR, 25-28 weeks) and a median birth weight of 880 g (IQR, 700-1170 g). The number of deaths decreased with each later epoch (from 671 to 473 and then to 360), as did the proportion of deaths from respiratory causes (64% to 62% and then to 49%). The proportion of deaths occurring after 40 weeks postmenstrual age remained stable across the 3 epochs (8.8%, 8%, and 8%). Deaths from infection and NEC increased with time (from 11% to 13% and then to 21%), as did median time to death (from 2.7 to 3.8 days). CONCLUSION: Infection and NEC are increasingly prevalent causes of death in preterm infants.
OBJECTIVE: To establish how cause of death for live-born preterm infants (24-31 weeks gestation) has changed in a single large UK population over 2 decades. STUDY DESIGN: This was an interrogation of a population-based survey of >680, 000 live births (between 1988 and 2008) for deaths in the first postnatal year. We collected cause of death grouped into major etiologies: respiratory, infection, malformation, necrotizing enterocolitis (NEC), and other. Data were analyzed in three 7-year epochs and 2 gestational groups (<27 and 28-31 weeks). Numbers, rates per 1000 live births, and proportional contributions to each epoch were analyzed. RESULTS: A total of 1504 deaths occurred. The infants who died had a median gestational age of 26 weeks (IQR, 25-28 weeks) and a median birth weight of 880 g (IQR, 700-1170 g). The number of deaths decreased with each later epoch (from 671 to 473 and then to 360), as did the proportion of deaths from respiratory causes (64% to 62% and then to 49%). The proportion of deaths occurring after 40 weeks postmenstrual age remained stable across the 3 epochs (8.8%, 8%, and 8%). Deaths from infection and NEC increased with time (from 11% to 13% and then to 21%), as did median time to death (from 2.7 to 3.8 days). CONCLUSION:Infection and NEC are increasingly prevalent causes of death in preterm infants.
Authors: Elizabeth A Marchant; Bernard Kan; Ashish A Sharma; Alice van Zanten; Tobias R Kollmann; Rollin Brant; Pascal M Lavoie Journal: Pediatr Res Date: 2015-07-17 Impact factor: 3.756
Authors: M Cetinkaya; T Erener-Ercan; T Kalayci-Oral; A Babayiğit; B Cebeci; S Y Semerci; G Buyukkale Journal: J Perinatol Date: 2017-03-23 Impact factor: 2.521
Authors: Deena Gibbons; Paul Fleming; Alex Virasami; Marie-Laure Michel; Neil J Sebire; Kate Costeloe; Robert Carr; Nigel Klein; Adrian Hayday Journal: Nat Med Date: 2014-09-21 Impact factor: 53.440
Authors: Kristin P Tully; Diane Holditch-Davis; Rosemary C White-Traut; Richard David; T Michael O'Shea; Victoria Geraldo Journal: J Obstet Gynecol Neonatal Nurs Date: 2015-11-25