OBJECTIVE: The objective of the study was to investigate the possible association between maternal/neonatal 25-hydroxy vitamin D (25-OHD) levels and development of necrotizing enterocolitis (NEC). STUDY DESIGN: One hundred and forty-five preterm infants ⩽36 weeks of gestation were enrolled. 25-OHD levels were determined in maternal/neonatal blood samples that were obtained at the time of admission to the neonatal intensive care unit. RESULTS: Of the 145 enrolled patients, 26 (18%) developed NEC. Maternal/neonatal 25-OHD levels in the NEC group were significantly lower than those of the no-NEC group (P=0.001 and 0.004, respectively). In univariate logistic regression analysis, both maternal/neonatal vitamin D levels were a significant predictor of NEC (odds ratio (OR): 0.92 and 0.89; P<0.001 and P<0.005, respectively). However, multivariate logistic regression analysis revealed that only maternal vitamin D level was a significant predictor of NEC (OR: 0.86, P<0.0009). CONCLUSION: This is the first study to propose a possible association between maternal/neonatal 25-OHD levels and subsequent development of NEC in preterm infants.
OBJECTIVE: The objective of the study was to investigate the possible association between maternal/neonatal 25-hydroxy vitamin D (25-OHD) levels and development of necrotizing enterocolitis (NEC). STUDY DESIGN: One hundred and forty-five preterm infants ⩽36 weeks of gestation were enrolled. 25-OHD levels were determined in maternal/neonatal blood samples that were obtained at the time of admission to the neonatal intensive care unit. RESULTS: Of the 145 enrolled patients, 26 (18%) developed NEC. Maternal/neonatal 25-OHD levels in the NEC group were significantly lower than those of the no-NEC group (P=0.001 and 0.004, respectively). In univariate logistic regression analysis, both maternal/neonatal vitamin D levels were a significant predictor of NEC (odds ratio (OR): 0.92 and 0.89; P<0.001 and P<0.005, respectively). However, multivariate logistic regression analysis revealed that only maternal vitamin D level was a significant predictor of NEC (OR: 0.86, P<0.0009). CONCLUSION: This is the first study to propose a possible association between maternal/neonatal 25-OHD levels and subsequent development of NEC in preterm infants.
Authors: M Cetinkaya; F Cekmez; G Buyukkale; T Erener-Ercan; F Demir; T Tunc; F N Aydın; G Aydemir Journal: J Perinatol Date: 2014-08-07 Impact factor: 2.521
Authors: Venu Lagishetty; Alexander V Misharin; Nancy Q Liu; Thomas S Lisse; Rene F Chun; Yi Ouyang; Sandra M McLachlan; John S Adams; Martin Hewison Journal: Endocrinology Date: 2010-04-14 Impact factor: 4.736
Authors: I González-Molero; G Rojo-Martínez; S Morcillo; C Gutierrez; E Rubio; V Pérez-Valero; I Esteva; M S Ruiz de Adana; M C Almaraz; N Colomo; G Olveira; F Soriguer Journal: Eur J Clin Nutr Date: 2013-02-20 Impact factor: 4.016
Authors: S Ardizzone; A Cassinotti; D Trabattoni; G Manzionna; V Rainone; M Bevilacqua; A Massari; G Manes; G Maconi; M Clerici; G Bianchi Porro Journal: Int J Immunopathol Pharmacol Date: 2009 Jan-Mar Impact factor: 3.219