| Literature DB >> 21866928 |
Mikhail Y Berezin1, Chun Zhan, Hyeran Lee, Chulmin Joo, Walter J Akers, Siavash Yazdanfar, Samuel Achilefu.
Abstract
Two-photon (2P) optical properties of cyanine dyes were evaluated using a 2P fluorescence spectrophotometer with 1.55 μm excitation. We report the 2P characteristics of common NIR polymethine dyes, including their 2P action cross sections and the 2P excited fluorescence lifetime. One of the dyes, DTTC, showed the highest 2P action cross-section (∼103 ± 19 GM) and relatively high 2P excited fluorescence lifetime and can be used as a scaffold for the synthesis of 2P molecular imaging probes. The 2P action cross-section of DTTC and the lifetime were also highly sensitive to the solvent polarity, providing other additional parameters for its use in optical imaging and the mechanism for probing environmental factors. Overall, this study demonstrated the quantitative measurement of 2P properties of NIR dyes and established the foundation for designing molecular probes for 2P imaging applications in the NIR region.Entities:
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Year: 2011 PMID： 21866928 PMCID： PMC3233988 DOI： 10.1021/jp207618e
Source DB: PubMed Journal: J Phys Chem B ISSN： 1520-5207 Impact factor: 2.991