OBJECTIVE: The extent of the digestive/absorptive involvement in atypical presentation of celiac disease (CD) is not always clear. The aim of the study was to assess nutritional status of iron (Fe), copper (Cu), and zinc (Zn) in patients with typical CD (TCD) and atypical CD (ACD). PATIENTS AND METHODS: A cross-sectional study was done in patients with TCD, ACD, and healthy controls (HC). Hemoglobin, serum ferritin, free erythrocyte protoporphyrin, Fe, Cu, ceruloplasmin, Zn, anti-endomysial antibodies, and anti-tissue transglutaminase antibodies were measured. Data were analyzed by Kruskal-Wallis, principal component analysis, and linear discriminant analysis. RESULTS: : One hundred nine individuals were studied (54 TCD, 19 ACD, 36 HC); mean age ± standard deviation was 23 ± 15.8 (range 1.6-75.4) years. Median and range of hemoglobin were 12.8 g/dL (8.1-17.6) in TCD, 12.4 g/dL (10.5-14.5) in ACD, and 13.6 g/dL (11.1-16.7) in HC (P < 0.0001); serum ferritin was 17.7 μg/L (2.9-157), 10.8 μg/L (2.7-39.8), and 28.7 μg/L (4.5-127.2), respectively (P < 0.01). Cu was 105 μg/dL (60-185), 97.5 μg/dL (40-130), and 125 μg/dL (80-205), respectively (P < 0.05). Ceruloplasmin was 21.6 mg/dL (14.2-73.2), 22.6 mg/dL (0.9-34.3), and 32.1 mg/dL (5.8-72.6), respectively (P < 0.01). There were no differences in Fe, free erythrocyte protoporphyrin, and Zn. Principal component analysis showed that 58% of observed variability was explained by Fe and Cu indicators. Linear discriminant analysis revealed differences between CD and HC (P < 0.0001), with high values of correct classification for TCD (73%) and HC (72%), but not ACD (16%), which were mostly classified as TCD (79%). CONCLUSIONS: Deficiency of micronutrients was found both in typical as well as in atypical cases.
OBJECTIVE: The extent of the digestive/absorptive involvement in atypical presentation of celiac disease (CD) is not always clear. The aim of the study was to assess nutritional status of iron (Fe), copper (Cu), and zinc (Zn) in patients with typical CD (TCD) and atypical CD (ACD). PATIENTS AND METHODS: A cross-sectional study was done in patients with TCD, ACD, and healthy controls (HC). Hemoglobin, serum ferritin, free erythrocyte protoporphyrin, Fe, Cu, ceruloplasmin, Zn, anti-endomysial antibodies, and anti-tissue transglutaminase antibodies were measured. Data were analyzed by Kruskal-Wallis, principal component analysis, and linear discriminant analysis. RESULTS: : One hundred nine individuals were studied (54 TCD, 19 ACD, 36 HC); mean age ± standard deviation was 23 ± 15.8 (range 1.6-75.4) years. Median and range of hemoglobin were 12.8 g/dL (8.1-17.6) in TCD, 12.4 g/dL (10.5-14.5) in ACD, and 13.6 g/dL (11.1-16.7) in HC (P < 0.0001); serum ferritin was 17.7 μg/L (2.9-157), 10.8 μg/L (2.7-39.8), and 28.7 μg/L (4.5-127.2), respectively (P < 0.01). Cu was 105 μg/dL (60-185), 97.5 μg/dL (40-130), and 125 μg/dL (80-205), respectively (P < 0.05). Ceruloplasmin was 21.6 mg/dL (14.2-73.2), 22.6 mg/dL (0.9-34.3), and 32.1 mg/dL (5.8-72.6), respectively (P < 0.01). There were no differences in Fe, free erythrocyte protoporphyrin, and Zn. Principal component analysis showed that 58% of observed variability was explained by Fe and Cu indicators. Linear discriminant analysis revealed differences between CD and HC (P < 0.0001), with high values of correct classification for TCD (73%) and HC (72%), but not ACD (16%), which were mostly classified as TCD (79%). CONCLUSIONS: Deficiency of micronutrients was found both in typical as well as in atypical cases.
Authors: Alberto Rubio-Tapia; Ivor D Hill; Ciarán P Kelly; Audrey H Calderwood; Joseph A Murray Journal: Am J Gastroenterol Date: 2013-04-23 Impact factor: 10.864
Authors: John A Coburn; Jennifer L Vande Voort; Brian D Lahr; Carol T Van Dyke; Cynthia M Kroning; Tsung-Teh Wu; Manish J Gandhi; Joseph A Murray Journal: J Clin Gastroenterol Date: 2013 Nov-Dec Impact factor: 3.062
Authors: Mounica Vallurupalli; Sanjay Divakaran; Aric Parnes; Bruce D Levy; Joseph Loscalzo Journal: N Engl J Med Date: 2019-10-03 Impact factor: 91.245
Authors: Markus Hahn; Alexander F Hagel; Simon Hirschmann; Caroline Bechthold; Peter Konturek; Markus Neurath; Martin Raithel Journal: Allergo J Int Date: 2014-03-19
Authors: Idoia Larretxi; Itziar Txurruka; Virginia Navarro; Arrate Lasa; María Ángeles Bustamante; María Del Pilar Fernández-Gil; Edurne Simón; Jonatan Miranda Journal: Foods Date: 2019-08-07