Literature DB >> 21865444

The large Rep protein of adeno-associated virus type 2 is polyubiquitinated.

Loretta Sukhu1, David Pintel1.   

Abstract

Five adenovirus (Ad) gene products are required for efficient replication of co-infecting adeno-associated virus (AAV); however, the combined net enhancement by these factors is composed of both positive and negative effects. Similar to previous results with AAV Rep52, AAV2 large Rep was targeted for ubiquitination and degradation by the Ad E4orf6/E1b 55 kDa, cullin 5-containing, E3-ubiquitin ligase. Additionally, large Rep was targeted for ubiquitination via extension of ubiquitin lysine K48 and K63 both in the presence and absence of E4orf6.

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Year:  2011        PMID： 21865444      PMCID： PMC3352567          DOI： 10.1099/vir.0.034975-0

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  17 in total

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Authors:  Kah Leong Lim; Katherine C M Chew; Jeanne M M Tan; Cheng Wang; Kenny K K Chung; Yi Zhang; Yuji Tanaka; Wanli Smith; Simone Engelender; Christopher A Ross; Valina L Dawson; Ted M Dawson
Journal:  J Neurosci       Date:  2005-02-23       Impact factor: 6.167

Review 2.  The emerging complexity of protein ubiquitination.

Authors:  David Komander
Journal:  Biochem Soc Trans       Date:  2009-10       Impact factor: 5.407

Review 3.  Biology of adeno-associated virus.

Authors:  K I Berns; C Giraud
Journal:  Curr Top Microbiol Immunol       Date:  1996       Impact factor: 4.291

Review 4.  Parkin-mediated lysine 63-linked polyubiquitination: a link to protein inclusions formation in Parkinson's and other conformational diseases?

Authors:  Kah-Leong Lim; Valina L Dawson; Ted M Dawson
Journal:  Neurobiol Aging       Date:  2005-10-06       Impact factor: 4.673

Review 5.  Targeting of substrates to the 26S proteasome.

Authors:  C M Pickart
Journal:  FASEB J       Date:  1997-11       Impact factor: 5.191

6.  Substrate-mediated regulation of cullin neddylation.

Authors:  Eng-Hui Chew; Thilo Hagen
Journal:  J Biol Chem       Date:  2007-04-17       Impact factor: 5.157

7.  Proteasomal turnover of p21Cip1 does not require p21Cip1 ubiquitination.

Authors:  R J Sheaff; J D Singer; J Swanger; M Smitherman; J M Roberts; B E Clurman
Journal:  Mol Cell       Date:  2000-02       Impact factor: 17.970

8.  SUMO-1 modification regulates the protein stability of the large regulatory protein Rep78 of adeno associated virus type 2 (AAV-2).

Authors:  Stefan Weger; Eva Hammer; Regine Heilbronn
Journal:  Virology       Date:  2004-12-05       Impact factor: 3.616

9.  Positive and negative effects of adenovirus type 5 helper functions on adeno-associated virus type 5 (AAV5) protein accumulation govern AAV5 virus production.

Authors:  Ramnath Nayak; David J Pintel
Journal:  J Virol       Date:  2006-12-13       Impact factor: 5.103

10.  Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation.

Authors:  Dietrich B Conze; Chuan-Jin Wu; James A Thomas; Allison Landstrom; Jonathan D Ashwell
Journal:  Mol Cell Biol       Date:  2008-03-17       Impact factor: 4.272
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  2 in total

1.  DNA Binding and Cleavage by the Human Parvovirus B19 NS1 Nuclease Domain.

Authors:  Jonathan L Sanchez; Zachary Romero; Angelica Quinones; Kristiane R Torgeson; Nancy C Horton
Journal:  Biochemistry       Date:  2016-11-17       Impact factor: 3.162

2.  Oligomeric properties of adeno-associated virus Rep68 reflect its multifunctionality.

Authors:  Francisco Zarate-Perez; Jorge Mansilla-Soto; Martino Bardelli; John W Burgner; Maria Villamil-Jarauta; Demet Kekilli; Monserrat Samso; R Michael Linden; Carlos R Escalante
Journal:  J Virol       Date:  2012-11-14       Impact factor: 5.103
  2 in total

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