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Literature DB >> 17166904

Positive and negative effects of adenovirus type 5 helper functions on adeno-associated virus type 5 (AAV5) protein accumulation govern AAV5 virus production.

Abstract

Full replication of adeno-associated virus type 5 (AAV5) is sustained by adenovirus type 5 (Ad5) helper functions E1a, E1b, E2a, E4Orf6, and virus-associated (VA) RNA; however, their combined net enhancement of AAV5 replication was comprised of both positive and negative individual effects. Although Ad5 E4Orf6 was required for AAV5 genomic DNA replication, it also functioned together with E1b to degrade de novo-expressed, preassembled AAV5 capsid proteins and Rep52 in a proteosome-dependent manner. VA RNA enhanced accumulation of AAV5 protein, overcoming the degradative effects of E4Orf6, and was thus required to restore adequate amounts of AAV5 proteins necessary to achieve efficient virus production.

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Year: 2006 PMID： 17166904 PMCID： PMC1865952 DOI： 10.1128/JVI.02312-06

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

23 in total

1. Characterization of the transcription profile of adeno-associated virus type 5 reveals a number of unique features compared to previously characterized adeno-associated viruses.

Authors: Jianming Qiu; Ramnath Nayak; Gregory E Tullis; David J Pintel
Journal: J Virol Date: 2002-12 Impact factor: 5.103

2. Efficient expression of the adeno-associated virus type 5 p41 capsid gene promoter in 293 cells does not require Rep.

Authors: Chaoyang Ye; Jianming Qiu; David J Pintel
Journal: J Virol Date: 2006-07 Impact factor: 5.103

3. DNA helicase-mediated packaging of adeno-associated virus type 2 genomes into preformed capsids.

Authors: J A King; R Dubielzig; D Grimm; J A Kleinschmidt
Journal: EMBO J Date: 2001-06-15 Impact factor: 11.598

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Authors: J M Ostrove; K I Berns
Journal: Virology Date: 1980-07-30 Impact factor: 3.616

5. Ubiquitination of both adeno-associated virus type 2 and 5 capsid proteins affects the transduction efficiency of recombinant vectors.

Authors: Ziying Yan; Roman Zak; G W Gant Luxton; Teresa C Ritchie; Ursula Bantel-Schaal; John F Engelhardt
Journal: J Virol Date: 2002-03 Impact factor: 5.103

6. Characterization of the DNA of a defective human parvovirus isolated from a genital site.

Authors: U Bantel-Schaal; H zur Hausen
Journal: Virology Date: 1984-04-15 Impact factor: 3.616

7. The Rep protein of adeno-associated virus type 2 interacts with single-stranded DNA-binding proteins that enhance viral replication.

Authors: Travis H Stracker; Geoffrey D Cassell; Peter Ward; Yueh-Ming Loo; Bas van Breukelen; Stacy D Carrington-Lawrence; Robert K Hamatake; Peter C van der Vliet; Sandra K Weller; Thomas Melendy; Matthew D Weitzman
Journal: J Virol Date: 2004-01 Impact factor: 5.103

8. Alternative polyadenylation of adeno-associated virus type 5 RNA within an internal intron is governed by both a downstream element within the intron 3' splice acceptor and an element upstream of the P41 initiation site.

Authors: Jianming Qiu; Ramnath Nayak; David J Pintel
Journal: J Virol Date: 2004-01 Impact factor: 5.103

9. Effect of deletions in adenovirus early region 1 genes upon replication of adeno-associated virus.

Authors: C A Laughlin; N Jones; B J Carter
Journal: J Virol Date: 1982-03 Impact factor: 5.103

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Authors: B Georg-Fries; S Biederlack; J Wolf; H zur Hausen
Journal: Virology Date: 1984-04-15 Impact factor: 3.616

9 in total

1. E4Orf6-E1B-55k-dependent degradation of de novo-generated adeno-associated virus type 5 Rep52 and capsid proteins employs a cullin 5-containing E3 ligase complex.

Authors: Ramnath Nayak; K David Farris; David J Pintel
Journal: J Virol Date: 2008-01-23 Impact factor: 5.103

2. Translation control by protein kinase R restricts minute virus of mice infection: role in parvovirus oncolysis.

Authors: Iván Ventoso; Juan J Berlanga; José M Almendral
Journal: J Virol Date: 2010-03-10 Impact factor: 5.103

3. The large Rep protein of adeno-associated virus type 2 is polyubiquitinated.

Authors: Loretta Sukhu; David Pintel
Journal: J Gen Virol Date: 2011-08-24 Impact factor: 3.891

4. Adeno-associated viruses can induce phosphorylation of eIF2alpha via PKR activation, which can be overcome by helper adenovirus type 5 virus-associated RNA.

Authors: Ramnath Nayak; David J Pintel
Journal: J Virol Date: 2007-08-22 Impact factor: 5.103

9. Efficient parvovirus replication requires CRL4Cdt2-targeted depletion of p21 to prevent its inhibitory interaction with PCNA.

Authors: Richard O Adeyemi; Matthew S Fuller; David J Pintel
Journal: PLoS Pathog Date: 2014-04-03 Impact factor: 6.823