Literature DB >> 21862631

TGF-β/SMAD/GLI2 signaling axis in cancer progression and metastasis.

Delphine Javelaud1, Vasileia I Alexaki, Sylviane Dennler, Khalid S Mohammad, Theresa A Guise, Alain Mauviel.   

Abstract

The Hedgehog (HH) and TGF-β signaling pathways represent essential regulators of cell proliferation and differentiation during embryogenesis. Pathway deregulation is a characteristic of various cancers. Recently, evidence for a convergence of these pathways at the level of the GLI2 transcription factor in the context of tumor initiation and progression to metastasis has emerged. This short review summarizes recent knowledge about GLI2 function and mechanisms of action downstream of TGF-β in cancer. ©2011 AACR.

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Year:  2011        PMID： 21862631      PMCID： PMC3165102          DOI： 10.1158/0008-5472.CAN-11-1194

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  39 in total

1.  Basal cell carcinomas in mice overexpressing Gli2 in skin.

Authors:  M Grachtchouk; R Mo; S Yu; X Zhang; H Sasaki; C C Hui; A A Dlugosz
Journal:  Nat Genet       Date:  2000-03       Impact factor: 38.330

2.  TGF-beta promotion of Gli2-induced expression of parathyroid hormone-related protein, an important osteolytic factor in bone metastasis, is independent of canonical Hedgehog signaling.

Authors:  Rachelle W Johnson; Mai P Nguyen; Susan S Padalecki; Barry G Grubbs; Alyssa R Merkel; Babatunde O Oyajobi; Lynn M Matrisian; Gregory R Mundy; Julie A Sterling
Journal:  Cancer Res       Date:  2010-12-28       Impact factor: 12.701

Review 3.  Activation of the hedgehog-signaling pathway in human cancer and the clinical implications.

Authors:  L Yang; G Xie; Q Fan; J Xie
Journal:  Oncogene       Date:  2009-11-23       Impact factor: 9.867

4.  Granulosa cell-expressed BMPR1A and BMPR1B have unique functions in regulating fertility but act redundantly to suppress ovarian tumor development.

Authors:  Mark A Edson; Roopa L Nalam; Caterina Clementi; Heather L Franco; Francesco J Demayo; Karen M Lyons; Stephanie A Pangas; Martin M Matzuk
Journal:  Mol Endocrinol       Date:  2010-04-02

Review 5.  Role of cadherins and matrixins in melanoma.

Authors:  C Gruss; M Herlyn
Journal:  Curr Opin Oncol       Date:  2001-03       Impact factor: 3.645

6.  Requirement of TGFbeta signaling for SMO-mediated carcinogenesis.

Authors:  Qipeng Fan; Miao He; Tao Sheng; Xiaoli Zhang; Mala Sinha; Bruce Luxon; Xingbo Zhao; Jingwu Xie
Journal:  J Biol Chem       Date:  2010-09-21       Impact factor: 5.157

Review 7.  Targeting the transforming growth factor-beta signalling pathway in metastatic cancer.

Authors:  Manav Korpal; Yibin Kang
Journal:  Eur J Cancer       Date:  2010-03-20       Impact factor: 9.162

8.  GLI2-mediated melanoma invasion and metastasis.

Authors:  Vasileia-Ismini Alexaki; Delphine Javelaud; Leon C L Van Kempen; Khalid S Mohammad; Sylviane Dennler; Flavie Luciani; Keith S Hoek; Patricia Juàrez; James S Goydos; Pierrick J Fournier; Claire Sibon; Corine Bertolotto; Franck Verrecchia; Simon Saule; Veronique Delmas; Robert Ballotti; Lionel Larue; Philippe Saiag; Theresa A Guise; Alain Mauviel
Journal:  J Natl Cancer Inst       Date:  2010-07-21       Impact factor: 13.506

9.  Gli2 functions in FGF signaling during antero-posterior patterning.

Authors:  R Brewster; J L Mullor; A Ruiz i Altaba
Journal:  Development       Date:  2000-10       Impact factor: 6.868

10.  Hypoxia and TGF-beta drive breast cancer bone metastases through parallel signaling pathways in tumor cells and the bone microenvironment.

Authors:  Lauren K Dunn; Khalid S Mohammad; Pierrick G J Fournier; C Ryan McKenna; Holly W Davis; Maria Niewolna; Xiang Hong Peng; John M Chirgwin; Theresa A Guise
Journal:  PLoS One       Date:  2009-09-03       Impact factor: 3.240
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  86 in total

1.  Identification and chromosomal localizations of signal transduction genes associated with human ovarian cancer metastasis.

Authors:  Zhu Xin; Xu Shenhua; Mou Hanzhou; Gu Linhui; Zhu Chihong; Liu Xianglin
Journal:  Med Oncol       Date:  2012-02-05       Impact factor: 3.064

Review 2.  Review: Experimental models for Barrett's esophagus and esophageal adenocarcinoma.

Authors:  Katherine S Garman; Roy C Orlando; Xiaoxin Chen
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2012-03-15       Impact factor: 4.052

3.  HER2-mediated GLI2 stabilization promotes anoikis resistance and metastasis of breast cancer cells.

Authors:  Parul Gupta; Nehal Gupta; Neel M Fofaria; Alok Ranjan; Sanjay K Srivastava
Journal:  Cancer Lett       Date:  2018-10-26       Impact factor: 8.679

4.  Crosstalk between SHH and stemness state signaling pathways in esophageal squamous cell carcinoma.

Authors:  Maryam Najafi; Mohammad Reza Abbaszadegan; Abolfazl Rad; Mahtab Dastpak; Samaneh Boroumand-Noughabi; Mohammad Mahdi Forghanifard
Journal:  J Cell Commun Signal       Date:  2016-11-30       Impact factor: 5.782

5.  Inhibition of Pancreatic Cancer Cell-Induced Paracrine Hedgehog Signaling by Liver X Receptor Agonists and Oxy16, a Naturally Occurring Oxysterol.

Authors:  Feng Wang; Frank Stappenbeck; William Matsui; Farhad Parhami
Journal:  J Cell Biochem       Date:  2016-09-21       Impact factor: 4.429

6.  Biallelic loss-of-function variants in PLD1 cause congenital right-sided cardiac valve defects and neonatal cardiomyopathy.

Authors:  Najim Lahrouchi; Alex V Postma; Christian M Salazar; Daniel M De Laughter; Fleur Tjong; Lenka Piherová; Forrest Z Bowling; Dominic Zimmerman; Elisabeth M Lodder; Asaf Ta-Shma; Zeev Perles; Leander Beekman; Aho Ilgun; Quinn Gunst; Mariam Hababa; Doris Škorić-Milosavljević; Viktor Stránecký; Viktor Tomek; Peter de Knijff; Rick de Leeuw; Jamille Y Robinson; Sabrina C Burn; Hiba Mustafa; Matthew Ambrose; Timothy Moss; Jennifer Jacober; Dmitriy M Niyazov; Barry Wolf; Katherine H Kim; Sara Cherny; Andreas Rousounides; Aphrodite Aristidou-Kallika; George Tanteles; Bruel Ange-Line; Anne-Sophie Denommé-Pichon; Christine Francannet; Damara Ortiz; Monique C Haak; Arend D.J. Ten Harkel; Gwendolyn Tr Manten; Annemiek C Dutman; Katelijne Bouman; Monia Magliozzi; Francesca Clementina Radio; Gijs We Santen; Johanna C Herkert; H Alex Brown; Orly Elpeleg; Maurice Jb van den Hoff; Barbara Mulder; Michael V Airola; Stanislav Kmoch; Joey V Barnett; Sally-Ann Clur; Michael A Frohman; Connie R Bezzina
Journal:  J Clin Invest       Date:  2021-03-01       Impact factor: 14.808

7.  Bitter melon juice exerts its efficacy against pancreatic cancer via targeting both bulk and cancer stem cells.

Authors:  Deepanshi Dhar; Gagan Deep; Sushil Kumar; Michael F Wempe; Komal Raina; Chapla Agarwal; Rajesh Agarwal
Journal:  Mol Carcinog       Date:  2018-05-18       Impact factor: 4.784

8.  Tetrahydrofurofuran-type lignans inhibit breast cancer-mediated bone destruction by blocking the vicious cycle between cancer cells, osteoblasts and osteoclasts.

Authors:  Ah Young Jun; Hyun-Jeong Kim; Kwang-Kyun Park; Kun Ho Son; Dong Hwa Lee; Mi-Hee Woo; Won-Yoon Chung
Journal:  Invest New Drugs       Date:  2013-05-15       Impact factor: 3.850

9.  Whole transcriptome analysis of the ERα synthetic fragment P295-T311 (ERα17p) identifies specific ERα-isoform (ERα, ERα36)-dependent and -independent actions in breast cancer cells.

Authors:  George Notas; Marilena Kampa; Vassiliki Pelekanou; Maria Troullinaki; Yves Jacquot; Guy Leclercq; Elias Castanas
Journal:  Mol Oncol       Date:  2013-02-20       Impact factor: 6.603

10.  Tumor-associated macrophages promote human hepatoma Huh-7 cell migration and invasion through the Gli2/IGF-II/ERK1/2 axis by secreting TGF-β1.

Authors:  Mei Liu; Yuan-Bin Zhong; Jia Shao; Cheng Zhang; Chao Shi
Journal:  Cancer Biol Ther       Date:  2020-10-21       Impact factor: 4.742
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