INTRODUCTION: Serum cystatin C was recently proposed as an alternative marker of glomerular filtration rate (GFR), with a suggested better performance than creatinine. However, detailed studies are limited. We evaluated the performance of cystatin C as a GFR marker. METHODS: GFR was measured by inulin clearance in 763 Japanese subjects. Factors other than GFR influencing serum cystatin C or serum creatinine were analyzed by multivariate analyses. RESULTS: After adjustment for GFR, the value of serum creatinine was 25.2% lower in females than males, and decreased by 5.2% for every 20 years of age. Serum cystatin C was 8.2% lower in females, and did not change significantly with aging. Creatinine but not cystatin C was significantly affected by body weight, height and body mass index after adjustment for GFR, gender and age. The correlation coefficient between GFR and 1/cystatin C was significantly higher than that of 1/creatinine in total subjects (0.866 and 0.810, respectively, p < 0.001). Unlike serum creatinine, serum cystatin C did not increase in association with the reduction of GFR in subjects with very low GFR. The regression line of 1/cystatin C against GFR showed a significantly negative intercept of about -8 ml/min/1.73 m(2). CONCLUSION: The performance of serum cystatin C was not good in the subjects with very low GFR. Non-renal elimination of cystatin C may contribute to the result. The correlation between reciprocal cystatin C and GFR suggested its superiority in predicting GFR compared to creatinine in subjects with normal and mildly reduced GFR.
INTRODUCTION: Serum cystatin C was recently proposed as an alternative marker of glomerular filtration rate (GFR), with a suggested better performance than creatinine. However, detailed studies are limited. We evaluated the performance of cystatin C as a GFR marker. METHODS: GFR was measured by inulin clearance in 763 Japanese subjects. Factors other than GFR influencing serum cystatin C or serum creatinine were analyzed by multivariate analyses. RESULTS: After adjustment for GFR, the value of serum creatinine was 25.2% lower in females than males, and decreased by 5.2% for every 20 years of age. Serum cystatin C was 8.2% lower in females, and did not change significantly with aging. Creatinine but not cystatin C was significantly affected by body weight, height and body mass index after adjustment for GFR, gender and age. The correlation coefficient between GFR and 1/cystatin C was significantly higher than that of 1/creatinine in total subjects (0.866 and 0.810, respectively, p < 0.001). Unlike serum creatinine, serum cystatin C did not increase in association with the reduction of GFR in subjects with very low GFR. The regression line of 1/cystatin C against GFR showed a significantly negative intercept of about -8 ml/min/1.73 m(2). CONCLUSION: The performance of serum cystatin C was not good in the subjects with very low GFR. Non-renal elimination of cystatin C may contribute to the result. The correlation between reciprocal cystatin C and GFR suggested its superiority in predicting GFR compared to creatinine in subjects with normal and mildly reduced GFR.
Authors: N Kotajima; Y Yanagawa; T Aoki; K Tsunekawa; T Morimura; T Ogiwara; M Nara; M Murakami Journal: J Int Med Res Date: 2010 Jul-Aug Impact factor: 1.671
Authors: Lesley A Stevens; Christopher H Schmid; Tom Greene; Liang Li; Gerald J Beck; Marshall M Joffe; Marc Froissart; John W Kusek; Yaping Lucy Zhang; Josef Coresh; Andrew S Levey Journal: Kidney Int Date: 2008-12-31 Impact factor: 10.612
Authors: Mark G Filipovic; Martin F Reiner; Saskia Rittirsch; Irina Irincheeva; Stefanie Aeschbacher; Kirsten Grossmann; Martin Risch; Lorenz Risch; Andreas Limacher; David Conen; Juerg H Beer Journal: Front Cardiovasc Med Date: 2021-04-27