Literature DB >> 20926009

Influence of thyroid hormones and transforming growth factor-β1 on cystatin C concentrations.

N Kotajima1, Y Yanagawa, T Aoki, K Tsunekawa, T Morimura, T Ogiwara, M Nara, M Murakami.   

Abstract

Serum cystatin C concentrations are reported to increase in the hyperthyroid state. Serum concentrations of cystatin C and transforming growth factor-β1 (TGF-β1) were measured in patients with thyroid dysfunction, and the effects of 3,5,3'-tri-iodothyronine (T(3)) and TGF-β1 on cystatin C production in human hepatoblastoma (Hep G2) cells were studied. Serum concentrations of cystatin C and TGF-β1 were significantly higher in patients with Graves' disease compared with control subjects. Significantly positive correlations were observed between thyroid hormones and cystatin C, thyroid hormones and TGF-β1, and TGF-β1 and cystatin C in patients with thyroid dysfunction. Serum concentrations of cystatin C and TGF-β1 decreased after treatment for hyperthyroidism. Cystatin C mRNA levels and cystatin C secretion were increased by T(3) and TGF-β1 in cultured Hep G2 cells. These results suggest that serum cystatin C concentrations increase in patients with hyperthyroidism. The mechanisms for this may involve elevation of serum TGF-β1 levels and the stimulatory effects of T(3) and TGF-β1 on cystatin C production.

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Year:  2010        PMID： 20926009     DOI： 10.1177/147323001003800418

Source DB:  PubMed          Journal:  J Int Med Res        ISSN： 0300-0605            Impact factor:   1.671


  14 in total

1.  Serum cystatin C as a potential biomarker for the evaluation COPD.

Authors:  Yonghong Zhang; Yanting Zhu; Yuanyuan Wu; Guizuo Wang; Xinming Xie; Rui Ke; Shaojun Li; Lu Liu; Wei Fen; Fengjuan Li; Fangxia Li; Manxiang Li
Journal:  Int J Clin Exp Med       Date:  2014-12-15

2.  Performance of serum cystatin C versus serum creatinine as a marker of glomerular filtration rate as measured by inulin renal clearance.

Authors:  Masaru Horio; Enyu Imai; Yoshinari Yasuda; Tsuyoshi Watanabe; Seiichi Matsuo
Journal:  Clin Exp Nephrol       Date:  2011-08-24       Impact factor: 2.801

3.  The impacts of thyroid function on the diagnostic accuracy of cystatin C to detect acute kidney injury in ICU patients: a prospective, observational study.

Authors:  Feilong Wang; Wenzhi Pan; Hairong Wang; Yu Zhou; Shuyun Wang; Shuming Pan
Journal:  Crit Care       Date:  2014-01-09       Impact factor: 9.097

Review 4.  Cystatin C is a disease-associated protein subject to multiple regulation.

Authors:  Yuekang Xu; Ying Ding; Xinchen Li; Xiaobing Wu
Journal:  Immunol Cell Biol       Date:  2015-02-03       Impact factor: 5.126

5.  Cystatin C relates to metabolism in healthy, pubertal adolescents.

Authors:  Niels Ziegelasch; Mandy Vogel; Antje Körner; Eva Koch; Anne Jurkutat; Uta Ceglarek; Katalin Dittrich; Wieland Kiess
Journal:  Pediatr Nephrol       Date:  2021-08-25       Impact factor: 3.714

6.  Multicenter study of creatinine- and/or cystatin C-based equations for estimation of glomerular filtration rates in Chinese patients with chronic kidney disease.

Authors:  Jia-fu Feng; Ling Qiu; Lin Zhang; Xue-mei Li; Yu-wei Yang; Ping Zeng; Xiu-zhi Guo; Yan Qin; Hong-chun Liu; Xing-min Han; Yan-peng Li; Wei Xu; Shu-yan Sun; Li-qiang Wang; Hui Quan; Li-jun Xia; Hong-zhang Hu; Fang-cai Zhong; Rong Duan
Journal:  PLoS One       Date:  2013-03-19       Impact factor: 3.240

7.  Impact of Growth Hormone on Cystatin C.

Authors:  Lisa Sze; René L Bernays; Cornelia Zwimpfer; Peter Wiesli; Michael Brändle; Christoph Schmid
Journal:  Nephron Extra       Date:  2013-11-20

Review 8.  Cystatin C: a new renal marker and its potential use in small animal medicine.

Authors:  L Ghys; D Paepe; P Smets; H Lefebvre; J Delanghe; S Daminet
Journal:  J Vet Intern Med       Date:  2014-05-09       Impact factor: 3.333

9.  Serum Cystatin C Concentrations in Patients with Graves' Ophthalmopathy.

Authors:  Nagehan Can; Ercan Ozsoy; Sabiha Gungor Kobat; Elif Yusufoglu; Nevin Ilhan; Tamer Demir
Journal:  Korean J Ophthalmol       Date:  2020-10-05

10.  Comparison of inulin clearance with 2-h creatinine clearance in Japanese pediatric patients with renal disease: open-label phase 3 study of inulin.

Authors:  Osamu Uemura; Kenji Ishikura; Koichi Kamei; Riku Hamada; Masaki Yamamoto; Yoshimitsu Gotoh; Naoya Fujita; Tomoyuki Sakai; Takafumi Sano; Masahiko Fushimi; Kazumoto Iijima
Journal:  Clin Exp Nephrol       Date:  2021-09-25       Impact factor: 2.801
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