| Literature DB >> 21859943 |
Wei Li1, Rama M Sakamuri, Danielle E Lyons, Florenda M Orcullo, Vidyagouri Shinde, Edred Lao Dela Pena, Armi A Maghanoy, Irene B Mallari, Esterlina V Tan, Indira Nath, Patrick J Brennan, Marivic Balagon, Varalakshmi Vissa.
Abstract
Drug resistance surveillance identified six untreated leprosy patients in the Philippines with Mycobacterium leprae folP1 mutations which confer dapsone resistance. Five patients share a village of residence; four who carried the mutation, Thr53Val, were also linked by M. leprae variable-number tandem repeat (VNTR) strain types. In India, folP1 mutations were detected in two relapse patients with a history of dapsone treatment. Mutations were not found in the rifampin target gene rpoB. These findings indicate that dapsone resistance is being transmitted.Entities:
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Year: 2011 PMID： 21859943 PMCID： PMC3195063 DOI： 10.1128/AAC.05236-11
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191