Literature DB >> 21857885

The Biology of TRAIL and the Role of TRAIL-Based Therapeutics in Infectious Diseases.

Brett D Shepard1, Andrew D Badley.   

Abstract

TNF-related apoptosis inducing ligand (TRAIL) is a key mediator of the innate immune response to infection. While TRAIL-mediated apoptosis plays an essential role in the clearance of virus-infected cells, its physiologic role also includes immunosurveilance for cancer cells. Therapeutics that induce TRAIL-mediated apoptosis in cancer cells remain a focus of ongoing investigation in clinical trials, and much has been learned from these studies regarding the efficacy and toxicity of these interventions. These data, combined with data from numerous preclinical studies that detail the important and multifaceted role of TRAIL during infection with human immunodeficiency virus and other viruses, suggest that therapeutic exploitation of TRAIL signaling offers a novel and efficacious strategy for the management of infectious diseases.

Entities:  

Year:  2009        PMID： 21857885      PMCID： PMC3158564          DOI： 10.2174/187152109787846060

Source DB:  PubMed          Journal:  Antiinfect Agents Med Chem        ISSN： 1871-5214


  181 in total

1.  Adenovirus E3-6.7K maintains calcium homeostasis and prevents apoptosis and arachidonic acid release.

Authors:  Alexander R Moise; Jason R Grant; Timothy Z Vitalis; Wilfred A Jefferies
Journal:  J Virol       Date:  2002-02       Impact factor: 5.103

2.  New apoptosis drugs face critical test.

Authors:  Ken Garber
Journal:  Nat Biotechnol       Date:  2005-04       Impact factor: 54.908

3.  The complementary roles of the extrinsic and intrinsic apoptotic pathways in promoting the death of cancer cells.

Authors:  Patrick A Mayes; Wafik S El-Deiry
Journal:  Cancer J       Date:  2006 Jul-Aug       Impact factor: 3.360

4.  IFN-gamma mediates a novel antiviral activity through dynamic modulation of TRAIL and TRAIL receptor expression.

Authors:  L M Sedger; D M Shows; R A Blanton; J J Peschon; R G Goodwin; D Cosman; S R Wiley
Journal:  J Immunol       Date:  1999-07-15       Impact factor: 5.422

5.  Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins.

Authors:  A M Verhagen; P G Ekert; M Pakusch; J Silke; L M Connolly; G E Reid; R L Moritz; R J Simpson; D L Vaux
Journal:  Cell       Date:  2000-07-07       Impact factor: 41.582

Review 6.  The promise of TRAIL--potential and risks of a novel anticancer therapy.

Authors:  Ronald Koschny; Henning Walczak; Tom M Ganten
Journal:  J Mol Med (Berl)       Date:  2007-04-17       Impact factor: 4.599

7.  Human herpesvirus 7 induces the functional up-regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) coupled to TRAIL-R1 down-modulation in CD4(+) T cells.

Authors:  P Secchiero; P Mirandola; D Zella; C Celeghini; A Gonelli; M Vitale; S Capitani; G Zauli
Journal:  Blood       Date:  2001-10-15       Impact factor: 22.113

8.  Adenovirus E1A oncogene expression in tumor cells enhances killing by TNF-related apoptosis-inducing ligand (TRAIL).

Authors:  J M Routes; S Ryan; A Clase; T Miura; A Kuhl; T A Potter; J L Cook
Journal:  J Immunol       Date:  2000-10-15       Impact factor: 5.422

9.  Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions.

Authors:  D Lawrence; Z Shahrokh; S Marsters; K Achilles; D Shih; B Mounho; K Hillan; K Totpal; L DeForge; P Schow; J Hooley; S Sherwood; R Pai; S Leung; L Khan; B Gliniak; J Bussiere; C A Smith; S S Strom; S Kelley; J A Fox; D Thomas; A Ashkenazi
Journal:  Nat Med       Date:  2001-04       Impact factor: 53.440

Review 10.  Emerging non-apoptotic functions of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/Apo2L.

Authors:  Roberta Di Pietro; Giorgio Zauli
Journal:  J Cell Physiol       Date:  2004-12       Impact factor: 6.384
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  8 in total

Review 1.  Clinical targeting of the TNF and TNFR superfamilies.

Authors:  Michael Croft; Chris A Benedict; Carl F Ware
Journal:  Nat Rev Drug Discov       Date:  2013-01-21       Impact factor: 84.694

2.  Caffeic acid phenethyl ester enhances TRAIL-mediated apoptosis via CHOP-induced death receptor 5 upregulation in hepatocarcinoma Hep3B cells.

Authors:  Matharage Gayani Dilshara; Rajapaksha Gedara Prasad Tharanga Jayasooriya; Sang Rul Park; Yung-Hyun Choi; Il-Whan Choi; Gi-Young Kim
Journal:  Mol Cell Biochem       Date:  2016-06-03       Impact factor: 3.396

3.  Cytokine, Chemokine, and Metalloprotease Activation in the Serum of Patients with Nephropathia Epidemica from the Republic of Tatarstan and the Republic of Mordovia, Russia.

Authors:  Ekaterina Martynova; Yuriy Davidyuk; Emmanuel Kabwe; Ekaterina E Garanina; Venera Shakirova; Vera Pavelkina; Yulia Uskova; Robert J Stott; Toshana L Foster; Maria Markelova; Mehendi Goyal; Abhimat Gupta; Mannan Bhola; Vinay Kumar; Manoj Baranwal; Albert A Rizvanov; Svetlana F Khaiboullina
Journal:  Pathogens       Date:  2021-04-27

Review 4.  Multiple Interactions Between Cancer Cells and the Tumor Microenvironment Modulate TRAIL Signaling: Implications for TRAIL Receptor Targeted Therapy.

Authors:  Margot de Looff; Steven de Jong; Frank A E Kruyt
Journal:  Front Immunol       Date:  2019-07-03       Impact factor: 7.561

5.  TRAIL/S-layer/graphene quantum dot nanohybrid enhanced stability and anticancer activity of TRAIL on colon cancer cells.

Authors:  Shima Lotfollahzadeh; Elaheh Sadat Hosseini; Hooman Mahmoudi Aznaveh; Maryam Nikkhah; Saman Hosseinkhani
Journal:  Sci Rep       Date:  2022-04-07       Impact factor: 4.996

6.  Mechanisms of foot-and-mouth disease virus tropism inferred from differential tissue gene expression.

Authors:  James J Zhu; Jonathan Arzt; Michael C Puckette; George R Smoliga; Juan M Pacheco; Luis L Rodriguez
Journal:  PLoS One       Date:  2013-05-28       Impact factor: 3.240

Review 7.  Virus Infection and Death Receptor-Mediated Apoptosis.

Authors:  Xingchen Zhou; Wenbo Jiang; Zhongshun Liu; Shuai Liu; Xiaozhen Liang
Journal:  Viruses       Date:  2017-10-27       Impact factor: 5.048

Review 8.  The Impact of the Interferon/TNF-Related Apoptosis-Inducing Ligand Signaling Axis on Disease Progression in Respiratory Viral Infection and Beyond.

Authors:  Christin Peteranderl; Susanne Herold
Journal:  Front Immunol       Date:  2017-03-22       Impact factor: 7.561
  8 in total

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