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Literature DB >> 2185745

Metabolism of hexacosatetraenoic acid (C26:4,n-6) in immature rat brain.

Abstract

Rat brain was recently found to contain polyenoic very-long-chain fatty acids (VLCFA) belonging to the n-3 and n-6 series with four, five and six double bonds and even-carbon chain lengths from 24 to 38 [Robinson, Johnson & Poulos (1990) Biochem. J. 265, 763-767]. In the present paper, the metabolism in vivo of hexacosatetraenoic acid (C26:4,n-6) was studied in neonatal rat brain. Rats were injected intracerebrally with [1-14C]C26:4,n-6 and the labelled metabolites were examined after 4 h. Radioactivity was detected mainly in non-esterified fatty acids, with smaller amounts in other neutral lipids and phospholipids. Radiolabelled fatty acid products included C28-36 tetraenoic and C26-28 pentaenoic VLCFA formed by elongation and desaturation of the substrate, and C14-24 saturated, C16-24 monoenoic, C18-24 dienoic, C18-22 trienoic and C20-24 tetraenoic fatty acids formed from released [1-14C]acetate either by synthesis de novo or by elongation of endogenous fatty acids. The data suggest that polyenoic VLCFA are synthesized in brain from shorter-chain precursor fatty acids and undergo beta-oxidation.

Entities: Chemical Gene Species

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Year: 1990 PMID： 2185745 PMCID： PMC1131329 DOI： 10.1042/bj2670561

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

23 in total

1. Detection of a homologous series of C26-C38 polyenoic fatty acids in the brain of patients without peroxisomes (Zellweger's syndrome).

Authors: A Poulos; P Sharp; H Singh; D Johnson; A Fellenberg; A Pollard
Journal: Biochem J Date: 1986-04-15 Impact factor: 3.857

2. Hydrogen transfer by NADPH-dependent reductases in elongation of very-long-chain saturated and polyunsaturated fatty-acyl-CoA in swine cerebral microsomes.

Authors: S Yoshida; T Saitoh; M Takeshita
Journal: Biochim Biophys Acta Date: 1988-02-19

3. Synthesis of very long chain (up to 36 carbon) tetra, penta and hexaenoic fatty acids in retina.

Authors: N P Rotstein; M I Aveldaño
Journal: Biochem J Date: 1988-01-01 Impact factor: 3.857

4. The occurrence of polyenoic very long chain fatty acids with greater than 32 carbon atoms in molecular species of phosphatidylcholine in normal and peroxisome-deficient (Zellweger's syndrome) brain.

Authors: A Poulos; P Sharp; D Johnson; C Easton
Journal: Biochem J Date: 1988-08-01 Impact factor: 3.857

5. Very long chain (C24 to C36) polyenoic fatty acids of the n-3 and n-6 series in dipolyunsaturated phosphatidylcholines from bovine retina.

Authors: M I Aveldaño; H Sprecher
Journal: J Biol Chem Date: 1987-01-25 Impact factor: 5.157

6. Fatty acid elongation activity in fibroblasts from patients with adrenoleukodystrophy (ALD).

Authors: S Tsuji; T Ohno; T Miyatake; A Suzuki; T Yamakawa
Journal: J Biochem Date: 1984-10 Impact factor: 3.387

7. Structure and lipid distribution of polyenoic very-long-chain fatty acids in the brain of peroxisome-deficient patients (Zellweger syndrome).

Authors: P Sharp; A Poulos; A Fellenberg; D Johnson
Journal: Biochem J Date: 1987-11-15 Impact factor: 3.857

8. Occurrence of unusual molecular species of sphingomyelin containing 28-34-carbon polyenoic fatty acids in ram spermatozoa.

Authors: A Poulos; D W Johnson; K Beckman; I G White; C Easton
Journal: Biochem J Date: 1987-12-15 Impact factor: 3.857

9. The occurrence of polyenoic fatty acids with greater than 22 carbon atoms in mammalian spermatozoa.

Authors: A Poulos; P Sharp; D Johnson; I White; A Fellenberg
Journal: Biochem J Date: 1986-12-15 Impact factor: 3.857

10. Inhibitory effect of very-long-chain monounsaturated fatty-acyl-CoAs on the elongation of long-chain fatty acid in swine cerebral microsomes.

Authors: T Saitoh; S Yoshida; M Takeshita
Journal: Biochim Biophys Acta Date: 1988-06-15

5 in total

Metabolism of hexacosatetraenoic acid (C26:4,n-6) in immature rat brain.

1. Detection of a homologous series of C26-C38 polyenoic fatty acids in the brain of patients without peroxisomes (Zellweger's syndrome).

2. Hydrogen transfer by NADPH-dependent reductases in elongation of very-long-chain saturated and polyunsaturated fatty-acyl-CoA in swine cerebral microsomes.

3. Synthesis of very long chain (up to 36 carbon) tetra, penta and hexaenoic fatty acids in retina.

4. The occurrence of polyenoic very long chain fatty acids with greater than 32 carbon atoms in molecular species of phosphatidylcholine in normal and peroxisome-deficient (Zellweger's syndrome) brain.

5. Very long chain (C24 to C36) polyenoic fatty acids of the n-3 and n-6 series in dipolyunsaturated phosphatidylcholines from bovine retina.

6. Fatty acid elongation activity in fibroblasts from patients with adrenoleukodystrophy (ALD).

7. Structure and lipid distribution of polyenoic very-long-chain fatty acids in the brain of peroxisome-deficient patients (Zellweger syndrome).

8. Occurrence of unusual molecular species of sphingomyelin containing 28-34-carbon polyenoic fatty acids in ram spermatozoa.

9. The occurrence of polyenoic fatty acids with greater than 22 carbon atoms in mammalian spermatozoa.

10. Inhibitory effect of very-long-chain monounsaturated fatty-acyl-CoAs on the elongation of long-chain fatty acid in swine cerebral microsomes.

Review 1. Retinal very long-chain PUFAs: new insights from studies on ELOVL4 protein.

2. Influence of very-long-chain polyunsaturated fatty acids on membrane structure and dynamics.

3. alpha-Synuclein abnormalities in mouse models of peroxisome biogenesis disorders.

Review 4. Very long chain fatty acids in higher animals--a review.

5. Regional changes in CNS and retinal glycerophospholipid profiles with age: a molecular blueprint.