Literature DB >> 2185743

Thiol-dependent metallo-endopeptidase characteristics of Pz-peptidase in rat and rabbit.

U Tisljar1, A J Barrett.   

Abstract

Pz-peptidase was purified from rat testis and rabbit muscle. Zinc was detectable in the rat enzyme. The activity of the enzyme from both species was slowly but completely abolished by EDTA and restored by Zn2+. Free thiol groups were also important for the catalytic activity of rat Pz-peptidase, as previously reported for the rabbit enzyme. We conclude that in both species Pz-peptidase has the characteristics of a thiol-dependent metallo-endopeptidase.

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Year:  1990        PMID： 2185743      PMCID： PMC1131321          DOI： 10.1042/bj2670531

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  11 in total

1.  The metalloenzymic nature of collagenase-like peptidase of the rat testis.

Authors:  J Lukac; E Koren
Journal:  J Reprod Fertil       Date:  1977-01

2.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Authors:  M M Bradford
Journal:  Anal Biochem       Date:  1976-05-07       Impact factor: 3.365

3.  Purification and characterization of Pz-peptidase from rabbit muscle.

Authors:  U Tisljar; A J Barrett
Journal:  Arch Biochem Biophys       Date:  1989-10       Impact factor: 4.013

4.  Studies on a peptidase acting on a synthetic collagenase substrate. Developmental pattern in rat granuloma tissue and distribution of enzyme in the tissues of various animals.

Authors:  S Aswanikumar; A N Radhakrishnan
Journal:  Biochim Biophys Acta       Date:  1973-03-30

5.  Preparation, assay, and partial characterization of a neutral endopeptidase from rabbit brain.

Authors:  A C Camargo; R Shapanka; L J Greene
Journal:  Biochemistry       Date:  1973-04-24       Impact factor: 3.162

6.  The activities of 'Pz-peptidase' and 'endopeptidase 24.15' are due to a single enzyme.

Authors:  A J Barrett; U Tisljar
Journal:  Biochem J       Date:  1989-08-01       Impact factor: 3.857

7.  Endopeptidase 24.15 from rat testes. Isolation of the enzyme and its specificity toward synthetic and natural peptides, including enkephalin-containing peptides.

Authors:  M Orlowski; S Reznik; J Ayala; A R Pierotti
Journal:  Biochem J       Date:  1989-08-01       Impact factor: 3.857

8.  Endooligopeptidase A activity in rabbit heart: generation of enkephalin from enkephalin containing peptides.

Authors:  M A Cicilini; M J Ribeiro; E B de Oliveira; R A Mortara; A C de Camargo
Journal:  Peptides       Date:  1988 Sep-Oct       Impact factor: 3.750

9.  Substrate-related potent inhibitors of brain metalloendopeptidase.

Authors:  M Orlowski; C Michaud; C J Molineaux
Journal:  Biochemistry       Date:  1988-01-26       Impact factor: 3.162

10.  A soluble metalloendopeptidase from rat brain. Purification of the enzyme and determination of specificity with synthetic and natural peptides.

Authors:  M Orlowski; C Michaud; T G Chu
Journal:  Eur J Biochem       Date:  1983-09-01
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  11 in total

1.  Thimet oligopeptidase (EC 3.4.24.15): the same by any name?

Authors:  A J Barrett
Journal:  Biochem J       Date:  1991-07-01       Impact factor: 3.857

2.  Characterization of PepB, a group B streptococcal oligopeptidase.

Authors:  B Lin; W F Averett; J Novak; W W Chatham; S K Hollingshead; J E Coligan; M L Egan; D G Pritchard
Journal:  Infect Immun       Date:  1996-08       Impact factor: 3.441

3.  Chicken liver Pz-peptidase, a thiol-dependent metallo-endopeptidase.

Authors:  A J Barrett; M A Brown
Journal:  Biochem J       Date:  1990-11-01       Impact factor: 3.857

4.  Rat thimet oligopeptidase: large-scale expression in Escherichia coli and characterization of the recombinant enzyme.

Authors:  N McKie; P M Dando; M A Brown; A J Barrett
Journal:  Biochem J       Date:  1995-07-01       Impact factor: 3.857

5.  Potent inhibition of endopeptidase 24.16 and endopeptidase 24.15 by the phosphonamide peptide N-(phenylethylphosphonyl)-Gly-L-Pro-L-aminohexanoic acid.

Authors:  H Barelli; V Dive; A Yiotakis; J P Vincent; F Checler
Journal:  Biochem J       Date:  1992-10-15       Impact factor: 3.857

6.  Purification and properties of a neurotensin-degrading endopeptidase from pig brain.

Authors:  P E Millican; A J Kenny; A J Turner
Journal:  Biochem J       Date:  1991-06-15       Impact factor: 3.857

7.  Evidence for the Existence in Arabidopsis thaliana of the Proteasome Proteolytic Pathway: ACTIVATION IN RESPONSE TO CADMIUM.

Authors:  Cécile Polge; Michel Jaquinod; Frances Holzer; Jacques Bourguignon; Linda Walling; Renaud Brouquisse
Journal:  J Biol Chem       Date:  2009-12-18       Impact factor: 5.157

8.  Endopeptidase 3.4.24.11 converts N-1-(R,S)carboxy-3-phenylpropyl-Ala-Ala-Phe-p-carboxyanilide into a potent inhibitor of angiotensin-converting enzyme.

Authors:  C H Williams; T Yamamoto; D M Walsh; D Allsop
Journal:  Biochem J       Date:  1993-09-15       Impact factor: 3.857

9.  Dimerization and thiol sensitivity of the salicylic acid binding thimet oligopeptidases TOP1 and TOP2 define their functions in redox-sensitive cellular pathways.

Authors:  Timothy J Westlake; William A Ricci; George V Popescu; Sorina C Popescu
Journal:  Front Plant Sci       Date:  2015-05-18       Impact factor: 5.753

10.  Recycling of the high valence States of heme proteins by cysteine residues of THIMET-oligopeptidase.

Authors:  Juliana C Ferreira; Marcelo Y Icimoto; Marcelo F Marcondes; Vitor Oliveira; Otaciro R Nascimento; Iseli L Nantes
Journal:  PLoS One       Date:  2013-11-01       Impact factor: 3.240
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