PURPOSE: We evaluated the efficacy of a novel catheter with a trefoil profile to decrease urothelial irritation and delay catheter associated urinary tract infections by comparing it with a conventional catheter in the rabbit model. MATERIALS AND METHODS: A novel catheter was made of medical silicone with a trefoil profile design. A total of 66 male New Zealand White rabbits were anesthetized and equally randomized into a control or a novel trefoil profile catheter group. Of the animals 10 per group were sacrificed at days 2, 4 and 8 of catheterization, respectively. Urine samples were cultured and urethral tissues were histopathologically evaluated. The remaining 6 rabbits were selected for urethral endoscopic assessment at day 10. RESULTS: After 4 days of catheterization the novel trefoil catheter profile decreased the rate of bacteriuria, defined as less than 100 cfu/ml, in 3 rabbits with a novel catheter vs that in 8 with a control catheter (p <0.05). Histopathological assessment revealed minor differences in staining in the short term. Endoscopic assessment showed more obvious mucosal inflammatory changes in 2 of the 3 controls than in the 3 rabbits with a novel catheter. CONCLUSIONS: Results demonstrate that the novel catheter harbors a property of decreasing urothelial irritation and delaying catheter associated urinary tract infection. This advantage over conventional catheters makes it a potential alternative for short-term catheterization. Clinical trials are forthcoming.
PURPOSE: We evaluated the efficacy of a novel catheter with a trefoil profile to decrease urothelial irritation and delay catheter associated urinary tract infections by comparing it with a conventional catheter in the rabbit model. MATERIALS AND METHODS: A novel catheter was made of medical silicone with a trefoil profile design. A total of 66 male New Zealand White rabbits were anesthetized and equally randomized into a control or a novel trefoil profile catheter group. Of the animals 10 per group were sacrificed at days 2, 4 and 8 of catheterization, respectively. Urine samples were cultured and urethral tissues were histopathologically evaluated. The remaining 6 rabbits were selected for urethral endoscopic assessment at day 10. RESULTS: After 4 days of catheterization the novel trefoil catheter profile decreased the rate of bacteriuria, defined as less than 100 cfu/ml, in 3 rabbits with a novel catheter vs that in 8 with a control catheter (p <0.05). Histopathological assessment revealed minor differences in staining in the short term. Endoscopic assessment showed more obvious mucosal inflammatory changes in 2 of the 3 controls than in the 3 rabbits with a novel catheter. CONCLUSIONS: Results demonstrate that the novel catheter harbors a property of decreasing urothelial irritation and delaying catheter associated urinary tract infection. This advantage over conventional catheters makes it a potential alternative for short-term catheterization. Clinical trials are forthcoming.
Authors: Jüri R Palisaar; Florian Roghmann; Marko Brock; Björn Löppenberg; Joachim Noldus; Christian von Bodman Journal: World J Urol Date: 2014-06-14 Impact factor: 4.226
Authors: Derya Tilki; Felix Preisser; Pierre Karakiewicz; Shahrokh F Shariat; Markus Graefen; Hartwig Huland; Felix K Chun; Raisa S Pompe Journal: World J Urol Date: 2018-03-26 Impact factor: 4.226
Authors: Yvonne J Cortese; Victoria E Wagner; Morgan Tierney; Declan Devine; Andrew Fogarty Journal: J Healthc Eng Date: 2018-10-14 Impact factor: 2.682