Myung Ki1, Theodora Pouliou, Leah Li, Chris Power. 1. MRC Centre of Epidemiology for Child Health, Centre for Paediatric Epidemiology and Biostatistics, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.
Abstract
OBJECTIVES: To investigate associations between physical (in)activity at different life-stages and lipids in mid-adulthood, examining the role of potential confounding and mediating factors, such as adiposity. METHODS: Data from the 1958 British birth cohort (n=7824) were examined. Using linear regression, we analysed prospectively reported frequency of activity and TV-viewing (23, 33, 42 and 45 y) in relation to total, LDL-, HDL-cholesterol and triglycerides, at 45 y. RESULTS: Activity at different ages was associated with HDL-cholesterol and triglycerides at 45 y: e.g. in men, a 1 day/week greater activity frequency at 42 y was associated with 0.006 mmol/L higher HDL-cholesterol and 1.4% lower triglycerides. Most associations attenuated, but were not entirely explained by adjustment for covariates (life-styles and socio-economic factors): e.g. among men, the estimated 2.0% lower triglycerides per 1 day/week greater frequency at 33 y reduced to 1.8% after adjustment. Among women, though not men, activity at both 23 and 45 y contributed cumulatively to HDL-cholesterol. For sedentary behaviour, associations were found for sitting at work: a 1 h/day greater sitting among men was associated with a 0.012 mmol/L lower HDL-cholesterol after adjustment for covariates. Associations were seen for TV-viewing: e.g. in men, a 0.04 mmol/L lower HDL-cholesterol and 5.9% higher triglycerides per hour/day greater TV-viewing at 45 y, attenuated, respectively, to 0.03 mmol/L and 4.6% after adjustment for covariates. Associations attenuated further after adjustment for current BMI. Associations for total and LDL-cholesterol were less consistent. CONCLUSION: Activity and sedentary behaviour at different adult ages were associated with HDL-cholesterol and triglycerides in mid-adulthood. Associations were partly mediated by other life-style factors and by BMI. Copyright Â
OBJECTIVES: To investigate associations between physical (in)activity at different life-stages and lipids in mid-adulthood, examining the role of potential confounding and mediating factors, such as adiposity. METHODS: Data from the 1958 British birth cohort (n=7824) were examined. Using linear regression, we analysed prospectively reported frequency of activity and TV-viewing (23, 33, 42 and 45 y) in relation to total, LDL-, HDL-cholesterol and triglycerides, at 45 y. RESULTS: Activity at different ages was associated with HDL-cholesterol and triglycerides at 45 y: e.g. in men, a 1 day/week greater activity frequency at 42 y was associated with 0.006 mmol/L higher HDL-cholesterol and 1.4% lower triglycerides. Most associations attenuated, but were not entirely explained by adjustment for covariates (life-styles and socio-economic factors): e.g. among men, the estimated 2.0% lower triglycerides per 1 day/week greater frequency at 33 y reduced to 1.8% after adjustment. Among women, though not men, activity at both 23 and 45 y contributed cumulatively to HDL-cholesterol. For sedentary behaviour, associations were found for sitting at work: a 1 h/day greater sitting among men was associated with a 0.012 mmol/L lower HDL-cholesterol after adjustment for covariates. Associations were seen for TV-viewing: e.g. in men, a 0.04 mmol/L lower HDL-cholesterol and 5.9% higher triglycerides per hour/day greater TV-viewing at 45 y, attenuated, respectively, to 0.03 mmol/L and 4.6% after adjustment for covariates. Associations attenuated further after adjustment for current BMI. Associations for total and LDL-cholesterol were less consistent. CONCLUSION: Activity and sedentary behaviour at different adult ages were associated with HDL-cholesterol and triglycerides in mid-adulthood. Associations were partly mediated by other life-style factors and by BMI. Copyright Â
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