Literature DB >> 21854808

Competitive inhibitor of cellular α-glucosidases protects mice from lethal dengue virus infection.

Jinhong Chang1, Wouter Schul, Andy Yip, Xiaodong Xu, Ju-Tao Guo, Timothy M Block.   

Abstract

Dengue virus infection causes diseases in people, ranging from the acute febrile illness dengue fever, to life-threatening dengue hemorrhagic fever/dengue shock syndrome. We previously reported that a host cellular α-glucosidases I and II inhibitor, imino sugar CM-10-18, potently inhibited dengue virus replication in cultured cells, and significantly reduced viremia in dengue virus infected AG129 mice. In this report we show that CM-10-18 also significantly protects mice from death and/or disease progress in two mouse models of lethal dengue virus infection. Our results thus provide a strong support for the development of CM-10-18 or its derivatives as antiviral agents to treat servere dengue virus infections.
Copyright © 2011 Elsevier B.V. All rights reserved.

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Year:  2011        PMID： 21854808      PMCID： PMC3209657          DOI： 10.1016/j.antiviral.2011.08.003

Source DB:  PubMed          Journal:  Antiviral Res        ISSN： 0166-3542            Impact factor:   5.970


  23 in total

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