Literature DB >> 21850438

Glutamate carboxypeptidase II (GCPII) inhibitor displays anti-glutamate and anti-cocaine effects in an invertebrate assay.

Chris Tallarida1, Kevin Song, Robert B Raffa, Scott M Rawls.   

Abstract

Glutamate carboxypeptidase II (GCPII) inhibitors are promising anti-glutamatergic and anti-addictive agents. We hypothesized that a GCPII inhibitor 2 (phosphonomethyl) pentanedioic acid (2-PMPA) would display anti-stereotypical activity in planarians. Experiments revealed that 2-PMPA displayed no overt behavioral activity by itself but attenuated stereotypical counts (C-shape hyperkinesias) elicited by four compounds (2-PMPA rank order potency: glutamate>NMDA>pilocarpine>cocaine). These data suggest GCPII inhibitors display broad-spectrum efficacy against behavioral activity produced by glutamatergic and non-glutamatergic compounds in an invertebrate assay.

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Year:  2011        PMID： 21850438      PMCID： PMC3265618          DOI： 10.1007/s00726-011-1052-6

Source DB:  PubMed          Journal:  Amino Acids        ISSN： 0939-4451            Impact factor:   3.520


  18 in total

1.  A pharmacological study of cocaine activity in planaria.

Authors:  G Palladini; S Ruggeri; F Stocchi; M F De Pandis; G Venturini; V Margotta
Journal:  Comp Biochem Physiol C Pharmacol Toxicol Endocrinol       Date:  1996-09

2.  Regulation of glutamate carboxypeptidase II hydrolysis of N-acetylaspartylglutamate (NAAG) in crayfish nervous tissue is mediated by glial glutamate and acetylcholine receptors.

Authors:  Albert K Urazaev; Robert M Grossfeld; Edward M Lieberman
Journal:  J Neurochem       Date:  2005-05       Impact factor: 5.372

3.  Cocaine withdrawal in Planaria.

Authors:  R B Raffa; J M Valdez
Journal:  Eur J Pharmacol       Date:  2001-10-26       Impact factor: 4.432

Review 4.  The neurotransmitter N-acetylaspartylglutamate in models of pain, ALS, diabetic neuropathy, CNS injury and schizophrenia.

Authors:  Joseph H Neale; Rafal T Olszewski; Laura M Gehl; Barbara Wroblewska; Tomasz Bzdega
Journal:  Trends Pharmacol Sci       Date:  2005-09       Impact factor: 14.819

5.  Effects of NAAG peptidase inhibitor 2-PMPA in model chronic pain - relation to brain concentration.

Authors:  Jens Nagel; Irina Belozertseva; Sergio Greco; Vladimir Kashkin; Andrey Malyshkin; Aigars Jirgensons; Elena Shekunova; Bernd Eilbacher; Anton Bespalov; Wojciech Danysz
Journal:  Neuropharmacology       Date:  2006-08-22       Impact factor: 5.250

6.  NAALADase (GCP II) inhibition prevents cocaine-kindled seizures.

Authors:  Jeffrey M Witkin; Maciej Gasior; Christina Schad; Agustin Zapata; Toni Shippenberg; Theresa Hartman; Barbara S Slusher
Journal:  Neuropharmacology       Date:  2002-09       Impact factor: 5.250

7.  Topiramate antagonizes NMDA- and AMPA-induced seizure-like activity in planarians.

Authors:  Scott M Rawls; Timmy Thomas; Mobilaji Adeola; Tanvi Patil; Natalie Raymondi; Asha Poles; Michael Loo; Robert B Raffa
Journal:  Pharmacol Biochem Behav       Date:  2009-05-15       Impact factor: 3.533

8.  Parthenolide prevents the expression of cocaine-induced withdrawal behavior in planarians.

Authors:  Amanda L Rowlands; Oné R Pagán
Journal:  Eur J Pharmacol       Date:  2008-01-26       Impact factor: 4.432

9.  Reversal of cocaine-induced planarian behavior by parthenolide and related sesquiterpene lactones.

Authors:  Oné R Pagán; Amanda L Rowlands; Mahrukh Azam; Kimberly R Urban; Apurva H Bidja; Danielle M Roy; Ryan B Feeney; Lilly K Afshari
Journal:  Pharmacol Biochem Behav       Date:  2007-12-15       Impact factor: 3.533

10.  N-acetylaspartylglutamate (NAAG) inhibits intravenous cocaine self-administration and cocaine-enhanced brain-stimulation reward in rats.

Authors:  Zheng-Xiong Xi; Michael Kiyatkin; Xia Li; Xiao-Qing Peng; Armina Wiggins; Krista Spiller; Jie Li; Eliot L Gardner
Journal:  Neuropharmacology       Date:  2009-06-24       Impact factor: 5.250
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  3 in total

1.  In vivo comparison of harmine efficacy against psychostimulants: preferential inhibition of the cocaine response through a glutamatergic mechanism.

Authors:  Suzan Owaisat; Robert B Raffa; Scott M Rawls
Journal:  Neurosci Lett       Date:  2012-08-03       Impact factor: 3.046

2.  Nicotine-induced C-shape movements in planarians are reduced by antinociceptive drugs: Implications for pain in planarian paroxysm etiology?

Authors:  Anthony Kim; Scott M Rawls
Journal:  Brain Res       Date:  2021-12-31       Impact factor: 3.252

Review 3.  The therapeutic and diagnostic potential of the prostate specific membrane antigen/glutamate carboxypeptidase II (PSMA/GCPII) in cancer and neurological disease.

Authors:  James C Evans; Meenakshi Malhotra; John F Cryan; Caitriona M O'Driscoll
Journal:  Br J Pharmacol       Date:  2016-09-23       Impact factor: 8.739
  3 in total

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