Literature DB >> 18275955

Parthenolide prevents the expression of cocaine-induced withdrawal behavior in planarians.

Amanda L Rowlands1, Oné R Pagán.   

Abstract

We recently reported that parthenolide and related sesquiterpene lactones are able to prevent and reverse behavioral responses in planarian worms induced by acute cocaine exposure. Previous reports indicate that when planarians are chronically exposed to microM concentrations of cocaine, they display stereotypical withdrawal-like behaviors when the cocaine is removed. Here we report that parthenolide prevents this cocaine-induced expression of planarian withdrawal-like behaviors.

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Year:  2008        PMID： 18275955     DOI： 10.1016/j.ejphar.2008.01.012

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


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