| Literature DB >> 21843897 |
Kazuhiko Otoguro1, Masato Iwatsuki, Aki Ishiyama, Miyuki Namatame, Aki Nishihara-Tukashima, Hiroaki Kiyohara, Toshihiro Hashimoto, Yoshinori Asakawa, Satoshi Omura, Haruki Yamada.
Abstract
During the course of screening to discover antitrypanosomal compounds, 24 known plant terpenes (6 sesquiterpenes, 14 sesquiterpene lactones and 4 diterpenes) were evaluated for in vitro antitrypanosomal activity against Trypanosoma brucei brucei. Among them, 22 terpenes exhibited antitrypanosomal activity. In particular, α-eudesmol, hinesol, nardosinone and 4-peroxy-1,2,4,5-tetrahydro-α-santonin all exhibited selective and potent antitrypanosomal activities in vitro. Detailed here in an in vitro antitrypanosomal properties and cytotoxicities of the 24 terpenes compared with two therapeutic antitrypanosomal drugs (eflornithine and suramin). This finding represents the first report of promising trypanocidal activity of these terpenes. Present results also provide some valuable insight with regard to structure-activity relationships and the possible mode of action of the compounds.Entities:
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Year: 2011 PMID： 21843897 DOI： 10.1016/j.phytochem.2011.07.015
Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072