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Literature DB >> 24998886

Roles played by acidic lipids in HIV-1 Gag membrane binding.

Abstract

The MA domain mediates plasma membrane (PM) targeting of HIV-1 Gag, leading to particle assembly at the PM. The interaction between MA and acidic phospholipids, in addition to N-terminal myristoyl moiety, promotes Gag binding to lipid membranes. Among acidic phospholipids, PI(4,5)P2, a PM-specific phosphoinositide, is essential for proper HIV-1 Gag localization to the PM and efficient virus particle production. Recent studies further revealed that MA-bound RNA negatively regulates HIV-1 Gag membrane binding and that PI(4,5)P2 is necessary to overcome this RNA-imposed block. In this review, we will summarize the current understanding of Gag-membrane interactions and discuss potential roles played by acidic phospholipids.

Entities: CellLine Chemical Disease Gene Species

Keywords: Acyl chains; HIV-1 Gag; Membrane binding; PI(4,5)P(2); Virus assembly

Mesh：

Substances：

Year: 2014 PMID： 24998886 PMCID： PMC4252750 DOI： 10.1016/j.virusres.2014.06.015

Source DB: PubMed Journal: Virus Res ISSN： 0168-1702 Impact factor: 3.303

122 in total

1. Entropic switch regulates myristate exposure in the HIV-1 matrix protein.

Authors: Chun Tang; Erin Loeliger; Paz Luncsford; Isaac Kinde; Dorothy Beckett; Michael F Summers
Journal: Proc Natl Acad Sci U S A Date: 2003-12-29 Impact factor: 11.205

2. Rous sarcoma virus gag has no specific requirement for phosphatidylinositol-(4,5)-bisphosphate for plasma membrane association in vivo or for liposome interaction in vitro.

Authors: Jany Chan; Robert A Dick; Volker M Vogt
Journal: J Virol Date: 2011-08-03 Impact factor: 5.103

3. Translation elongation factor 1-alpha interacts specifically with the human immunodeficiency virus type 1 Gag polyprotein.

Authors: A Cimarelli; J Luban
Journal: J Virol Date: 1999-07 Impact factor: 5.103

4. Comparative lipidomics analysis of HIV-1 particles and their producer cell membrane in different cell lines.

Authors: Maier Lorizate; Timo Sachsenheimer; Bärbel Glass; Anja Habermann; Mathias J Gerl; Hans-Georg Kräusslich; Britta Brügger
Journal: Cell Microbiol Date: 2013-01-10 Impact factor: 3.715

5. Patchwork organization of the yeast plasma membrane into numerous coexisting domains.

Authors: Felix Spira; Nikola S Mueller; Gisela Beck; Philipp von Olshausen; Joachim Beig; Roland Wedlich-Söldner
Journal: Nat Cell Biol Date: 2012-04-29 Impact factor: 28.824

6. Sequence-specific interaction between HIV-1 matrix protein and viral genomic RNA revealed by in vitro genetic selection.

Authors: P Purohit; S Dupont; M Stevenson; M R Green
Journal: RNA Date: 2001-04 Impact factor: 4.942

7. Analysis of human immunodeficiency virus type 1 matrix binding to membranes and nucleic acids.

Authors: Ayna Alfadhli; Amelia Still; Eric Barklis
Journal: J Virol Date: 2009-09-23 Impact factor: 5.103

8. Opposing mechanisms involving RNA and lipids regulate HIV-1 Gag membrane binding through the highly basic region of the matrix domain.

Authors: Vineela Chukkapalli; Seung J Oh; Akira Ono
Journal: Proc Natl Acad Sci U S A Date: 2010-01-04 Impact factor: 11.205

Review 9. Membrane targeting of lipid modified signal transduction proteins.

Authors: Marilyn D Resh
Journal: Subcell Biochem Date: 2004

10. Segregation of PIP2 and PIP3 into distinct nanoscale regions within the plasma membrane.

Authors: Jie Wang; David A Richards
Journal: Biol Open Date: 2012-07-10 Impact factor: 2.422

18 in total

1. Visualization of HIV-1 Gag Binding to Giant Unilamellar Vesicle (GUV) Membranes.

Authors: Balaji Olety; Sarah L Veatch; Akira Ono
Journal: J Vis Exp Date: 2016-07-28 Impact factor: 1.355

2. HIV-1 matrix-31 membrane binding peptide interacts differently with membranes containing PS vs. PI(4,5)P₂.

Authors: Lauren O'Neil; Kathryn Andenoro; Isabella Pagano; Laura Carroll; Leah Langer; Zachary Dell; Davina Perera; Bradley W Treece; Frank Heinrich; Mathias Lösche; John F Nagle; Stephanie Tristram-Nagle
Journal: Biochim Biophys Acta Date: 2016-09-15

3. Host Cell Plasma Membrane Phosphatidylserine Regulates the Assembly and Budding of Ebola Virus.

Authors: Emmanuel Adu-Gyamfi; Kristen A Johnson; Mark E Fraser; Jordan L Scott; Smita P Soni; Keaton R Jones; Michelle A Digman; Enrico Gratton; Charles R Tessier; Robert V Stahelin
Journal: J Virol Date: 2015-07-01 Impact factor: 5.103

4. The HIV-1 nucleocapsid protein recruits negatively charged lipids to ensure its optimal binding to lipid membranes.

Authors: Noémie Kempf; Viktoriia Postupalenko; Saurabh Bora; Pascal Didier; Youri Arntz; Hugues de Rocquigny; Yves Mély
Journal: J Virol Date: 2014-11-19 Impact factor: 5.103

5. Atomic view of the HIV-1 matrix lattice; implications on virus assembly and envelope incorporation.

Authors: Alexandra B Samal; Todd J Green; Jamil S Saad
Journal: Proc Natl Acad Sci U S A Date: 2022-06-03 Impact factor: 12.779

Review 6. HIV-1 Gag as an Antiviral Target: Development of Assembly and Maturation Inhibitors.

Authors: Paul Spearman
Journal: Curr Top Med Chem Date: 2016 Impact factor: 3.295

7. The matrix domain of the Gag protein from avian sarcoma virus contains a PI(4,5)P₂-binding site that targets Gag to the cell periphery.

Authors: Susan M Watanabe; Gisselle N Medina; Gunnar N Eastep; Ruba H Ghanam; Jiri Vlach; Jamil S Saad; Carol A Carter
Journal: J Biol Chem Date: 2018-10-11 Impact factor: 5.157