| Literature DB >> 21838278 |
Dmitry Tsvelikhovsky1, Stephen L Buchwald.
Abstract
A general and highly efficient protocol for the synthesis of dibenzodiazepines and their structural analogues is reported. In the presence of catalytic quantities of palladium, readily accessible precursors are cross-coupled with ammonia and then spontaneously undergo an intramolecular condensation to form the corresponding dibenzodiazepines in one step. This new strategy is applicable to the construction of a wide variety of dibenzooxazepines and other structurally related heterocycles.Entities:
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Year: 2011 PMID： 21838278 PMCID： PMC3175814 DOI： 10.1021/ja206229y
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419