BACKGROUND: Our aim was to grade MRI-detected skull-base invasion in nasopharyngeal carcinoma and evaluate the prognostic value of the grading. METHODS: The MRI scans and medical records of 924 patients with histologically diagnosed nondisseminated nasopharyngeal carcinoma were reviewed retrospectively. RESULTS: MRI-detected skull-base invasion was not found to be an independent prognostic factor for overall survival, distant metastasis-free survival, or local relapse-free survival (p > .05 for all). Grading of skull-base erosion according to the site of invasion was found to be an independent prognostic factor for both overall survival (p = .003 and p = .006, respectively) and distant metastasis-free survival (p = .001 for both) in the 512 patients with skull-base invasions and 315 patients with T3 disease. CONCLUSIONS: MRI-detected skull-base invasion is not an independent prognostic factor for nasopharyngeal carcinoma. However, grading according to the site of invasion as either low grade or severe has prognostic value.
BACKGROUND: Our aim was to grade MRI-detected skull-base invasion in nasopharyngeal carcinoma and evaluate the prognostic value of the grading. METHODS: The MRI scans and medical records of 924 patients with histologically diagnosed nondisseminated nasopharyngeal carcinoma were reviewed retrospectively. RESULTS: MRI-detected skull-base invasion was not found to be an independent prognostic factor for overall survival, distant metastasis-free survival, or local relapse-free survival (p > .05 for all). Grading of skull-base erosion according to the site of invasion was found to be an independent prognostic factor for both overall survival (p = .003 and p = .006, respectively) and distant metastasis-free survival (p = .001 for both) in the 512 patients with skull-base invasions and 315 patients with T3 disease. CONCLUSIONS: MRI-detected skull-base invasion is not an independent prognostic factor for nasopharyngeal carcinoma. However, grading according to the site of invasion as either low grade or severe has prognostic value.
Authors: Qi-Yong Ai; Chen-Wen Hu; Kunwar S Bhatia; Darren M C Poon; Edwin P Hui; Frankie K F Mo; Benjamin King Hong Law; Macy Tong; Brigette B Ma; Anthony T C Chan; Ann D King Journal: Eur Arch Otorhinolaryngol Date: 2017-11-29 Impact factor: 2.503
Authors: Yi-Kan Cheng; Li-Zhi Liu; Ning Jiang; Dan Yue; Ling-Long Tang; Fan Zhang; Li Lin; Xu Liu; Lei Chen; Jun Ma Journal: Strahlenther Onkol Date: 2014-04-25 Impact factor: 3.621
Authors: Aron Popovtzer; Mohannad Ibrahim; Daniel Tatro; Felix Y Feng; Randall K Ten Haken; Avraham Eisbruch Journal: Radiol Oncol Date: 2014-07-10 Impact factor: 2.991