Methyl 4-hy-droxy-2-isopropyl-1,1-dioxo-2H-1,2-benzothia-zine-3-carboxyl-ate.

In the crystal structure of the title mol-ecule, C(13)H(15)NO(5)S, the S and N atoms of the thia-zine ring exihibit the maximum deviations from the least-squares plane of 0.3008 (6) and 0.3280 (7) Å, respectively. The ring therefore adopts a half chair conformation. The thia-zine ring is twisted by an angle of 13.29 (7)° with respect to the aromatic ring. The isopropyl substituent is oriented at a dihedral angle of 53.2 (12)° with respect to the thia-zine ring. An intra-molecular O-H⋯O hydrogen bond occurs. Inter-molecular hydrogen bonding is observed in the crystal structure.

Related literature

For the synthetic procedure, see: Arshad et al. (2011 ▶). For the biological activity of related compounds, see: Lombardino et al. (1971 ▶); Vidal et al. (2006 ▶); Turck et al. (1996) ▶; Zia-ur-Rehman et al. (2006 ▶). For related structures, see: Arshad et al. (2008 ▶, 2009 ▶). For graph-set analysis, see Bernstein et al. (1995 ▶).

Experimental

Crystal data

C13H15NO5S

M = 297.32

Monoclinic,

a = 11.3896 (6) Å

b = 9.8421 (5) Å

c = 12.7680 (7) Å

β = 105.782 (1)°

V = 1377.31 (13) Å3

Z = 4

Mo Kα radiation

μ = 0.25 mm−1

T = 100 K

0.43 × 0.27 × 0.27 mm

Data collection

Siemens SMART 1K diffractometer with a Bruker APEXII detector

Absorption correction: multi-scan (SADABS; Bruker 2001 ▶) T min = 0.899, T max = 0.949

16137 measured reflections

3380 independent reflections

2967 reflections with I > 2σ(I)

R int = 0.024

Refinement

R[F 2 > 2σ(F 2)] = 0.034

wR(F 2) = 0.092

S = 1.06

3380 reflections

187 parameters

H atoms treated by a mixture of independent and constrained refinement

Δρmax = 0.43 e Å−3

Δρmin = −0.40 e Å−3

Data collection: APEX2 (Bruker, 2001 ▶); cell refinement: SAINT (Bruker, 2001 ▶); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008 ▶); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008 ▶); molecular graphics: ORTEP-3 (Farrugia, 1997 ▶) and PLATON (Spek, 2009 ▶); software used to prepare material for publication: WinGX (Farrugia, 1999 ▶) and PLATON.

Crystal structure: contains datablock(s) I, global. DOI: 10.1107/S1600536811024573/im2299sup1.cif

Structure factors: contains datablock(s) I. DOI: 10.1107/S1600536811024573/im2299Isup2.hkl

Supplementary material file. DOI: 10.1107/S1600536811024573/im2299Isup3.cml

Additional supplementary materials: crystallographic information; 3D view; checkCIF report

C13H15NO5S	F(000) = 624
Mr = 297.32	Dx = 1.434 Mg m−3
Monoclinic, P21/n	Mo Kα radiation, λ = 0.71073 Å
Hall symbol: -P 2yn	Cell parameters from 7059 reflections
a = 11.3896 (6) Å	θ = 2.7–28.4°
b = 9.8421 (5) Å	µ = 0.25 mm−1
c = 12.7680 (7) Å	T = 100 K
β = 105.782 (1)°	Needle, colorless
V = 1377.31 (13) Å3	0.43 × 0.27 × 0.27 mm
Z = 4

Siemens SMART 1K diffractometer with a Bruker APEXII detector	3380 independent reflections
Radiation source: fine-focus sealed tube	2967 reflections with I > 2σ(I)
graphite	Rint = 0.024
φ and ω scans	θmax = 28.4°, θmin = 2.1°
Absorption correction: multi-scan (SADABS; Bruker 2001)	h = −15→15
Tmin = 0.899, Tmax = 0.949	k = −13→12
16137 measured reflections	l = −16→16

Refinement on F2	Primary atom site location: structure-invariant direct methods
Least-squares matrix: full	Secondary atom site location: difference Fourier map
R[F2 > 2σ(F2)] = 0.034	Hydrogen site location: inferred from neighbouring sites
wR(F2) = 0.092	H atoms treated by a mixture of independent and constrained refinement
S = 1.06	w = 1/[σ2(Fo2) + (0.0464P)2 + 0.6953P] where P = (Fo2 + 2Fc2)/3
3380 reflections	(Δ/σ)max < 0.001
187 parameters	Δρmax = 0.43 e Å−3
0 restraints	Δρmin = −0.40 e Å−3

Geometry. All s.u.'s (except the s.u. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell s.u.'s are taken into account individually in the estimation of s.u.'s in distances, angles and torsion angles; correlations between s.u.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell s.u.'s is used for estimating s.u.'s involving l.s. planes.

Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > 2σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

	x	y	z	Uiso*/Ueq
S1	0.45158 (3)	0.80155 (3)	0.24103 (3)	0.01449 (10)
O1	0.41963 (9)	0.73289 (10)	0.32827 (8)	0.0204 (2)
O2	0.46334 (9)	0.72358 (10)	0.14956 (8)	0.0208 (2)
O4	0.32490 (9)	1.14730 (11)	−0.03579 (8)	0.0239 (2)
O5	0.19108 (9)	1.00457 (10)	0.00818 (8)	0.0206 (2)
O3	0.54813 (10)	1.14548 (11)	0.08196 (9)	0.0235 (2)
N1	0.35223 (10)	0.92191 (11)	0.19471 (9)	0.0148 (2)
C1	0.58852 (11)	0.89070 (13)	0.29337 (10)	0.0144 (2)
C2	0.67716 (12)	0.84231 (14)	0.38274 (11)	0.0167 (3)
H2	0.6646	0.7626	0.4174	0.020*
C3	0.78531 (12)	0.91527 (15)	0.41972 (11)	0.0194 (3)
H3	0.8463	0.8834	0.4788	0.023*
C4	0.80243 (13)	1.03493 (15)	0.36896 (12)	0.0213 (3)
H4	0.8745	1.0835	0.3950	0.026*
C5	0.71319 (13)	1.08340 (15)	0.27951 (11)	0.0207 (3)
H5	0.7258	1.1639	0.2459	0.025*
C6	0.60455 (12)	1.01095 (14)	0.24018 (11)	0.0163 (3)
C7	0.50866 (12)	1.05859 (14)	0.14559 (11)	0.0171 (3)
C8	0.39091 (12)	1.01442 (13)	0.12351 (11)	0.0159 (3)
C9	0.30108 (12)	1.06172 (14)	0.02519 (11)	0.0180 (3)
C10	0.09884 (14)	1.05700 (17)	−0.08516 (12)	0.0271 (3)
H10A	0.0828	1.1505	−0.0728	0.041*
H10B	0.0252	1.0051	−0.0954	0.041*
H10C	0.1276	1.0500	−0.1490	0.041*
C11	0.28252 (12)	0.98889 (14)	0.26547 (11)	0.0181 (3)
H11	0.2354	1.0621	0.2214	0.022*
C13	0.36474 (14)	1.05728 (17)	0.36523 (12)	0.0258 (3)
H13A	0.4031	0.9894	0.4173	0.039*
H13B	0.3170	1.1166	0.3970	0.039*
H13C	0.4262	1.1091	0.3444	0.039*
C12	0.18920 (13)	0.89440 (17)	0.29256 (13)	0.0263 (3)
H12A	0.1452	0.8473	0.2280	0.039*
H12B	0.1332	0.9466	0.3205	0.039*
H12C	0.2303	0.8297	0.3464	0.039*
H3O	0.482 (2)	1.167 (2)	0.0300 (17)	0.039*

	U11	U22	U33	U12	U13	U23
S1	0.01430 (16)	0.01178 (16)	0.01607 (17)	0.00005 (11)	0.00187 (12)	0.00036 (11)
O1	0.0185 (5)	0.0178 (5)	0.0237 (5)	−0.0013 (4)	0.0035 (4)	0.0067 (4)
O2	0.0194 (5)	0.0180 (5)	0.0225 (5)	0.0020 (4)	0.0015 (4)	−0.0060 (4)
O4	0.0277 (5)	0.0229 (5)	0.0188 (5)	0.0008 (4)	0.0023 (4)	0.0069 (4)
O5	0.0186 (5)	0.0226 (5)	0.0176 (5)	0.0017 (4)	−0.0002 (4)	0.0023 (4)
O3	0.0259 (5)	0.0252 (5)	0.0178 (5)	−0.0055 (4)	0.0033 (4)	0.0078 (4)
N1	0.0158 (5)	0.0139 (5)	0.0145 (5)	0.0027 (4)	0.0041 (4)	0.0021 (4)
C1	0.0147 (6)	0.0149 (6)	0.0138 (6)	−0.0013 (5)	0.0043 (5)	−0.0027 (5)
C2	0.0189 (6)	0.0158 (6)	0.0157 (6)	0.0011 (5)	0.0055 (5)	0.0003 (5)
C3	0.0172 (6)	0.0237 (7)	0.0157 (6)	0.0019 (5)	0.0020 (5)	−0.0018 (5)
C4	0.0175 (6)	0.0252 (7)	0.0205 (7)	−0.0058 (5)	0.0042 (5)	−0.0036 (6)
C5	0.0225 (7)	0.0209 (7)	0.0190 (7)	−0.0056 (5)	0.0063 (5)	0.0019 (5)
C6	0.0179 (6)	0.0180 (6)	0.0134 (6)	−0.0011 (5)	0.0048 (5)	−0.0003 (5)
C7	0.0228 (7)	0.0153 (6)	0.0137 (6)	−0.0013 (5)	0.0054 (5)	0.0003 (5)
C8	0.0199 (6)	0.0142 (6)	0.0133 (6)	0.0006 (5)	0.0037 (5)	0.0007 (5)
C9	0.0214 (6)	0.0160 (6)	0.0161 (6)	0.0020 (5)	0.0040 (5)	−0.0008 (5)
C10	0.0232 (7)	0.0304 (8)	0.0220 (7)	0.0037 (6)	−0.0036 (6)	0.0038 (6)
C11	0.0191 (6)	0.0181 (6)	0.0182 (7)	0.0042 (5)	0.0072 (5)	0.0004 (5)
C13	0.0286 (8)	0.0290 (8)	0.0211 (7)	0.0014 (6)	0.0091 (6)	−0.0053 (6)
C12	0.0212 (7)	0.0291 (8)	0.0314 (8)	0.0017 (6)	0.0117 (6)	0.0037 (6)

S1—O1	1.4319 (10)	C4—H4	0.9300
S1—O2	1.4338 (10)	C5—C6	1.3978 (19)
S1—N1	1.6338 (11)	C5—H5	0.9300
S1—C1	1.7556 (13)	C6—C7	1.4675 (18)
O4—C9	1.2264 (17)	C7—C8	1.3644 (19)
O5—C9	1.3361 (17)	C8—C9	1.4632 (18)
O5—C10	1.4524 (16)	C10—H10A	0.9600
O3—C7	1.3387 (16)	C10—H10B	0.9600
O3—H3O	0.88 (2)	C10—H10C	0.9600
N1—C8	1.4378 (17)	C11—C13	1.518 (2)
N1—C11	1.5072 (16)	C11—C12	1.521 (2)
C1—C2	1.3862 (18)	C11—H11	0.9800
C1—C6	1.4009 (18)	C13—H13A	0.9600
C2—C3	1.3926 (19)	C13—H13B	0.9600
C2—H2	0.9300	C13—H13C	0.9600
C3—C4	1.383 (2)	C12—H12A	0.9600
C3—H3	0.9300	C12—H12B	0.9600
C4—C5	1.390 (2)	C12—H12C	0.9600
O1—S1—O2	118.74 (6)	C8—C7—C6	122.54 (12)
O1—S1—N1	109.04 (6)	C7—C8—N1	121.61 (12)
O2—S1—N1	107.59 (6)	C7—C8—C9	119.64 (12)
O1—S1—C1	109.10 (6)	N1—C8—C9	118.75 (11)
O2—S1—C1	107.90 (6)	O4—C9—O5	123.06 (12)
N1—S1—C1	103.39 (6)	O4—C9—C8	122.64 (13)
C9—O5—C10	114.88 (11)	O5—C9—C8	114.29 (12)
C7—O3—H3O	104.6 (14)	O5—C10—H10A	109.5
C8—N1—C11	113.82 (10)	O5—C10—H10B	109.5
C8—N1—S1	112.76 (9)	H10A—C10—H10B	109.5
C11—N1—S1	121.74 (9)	O5—C10—H10C	109.5
C2—C1—C6	121.84 (12)	H10A—C10—H10C	109.5
C2—C1—S1	120.95 (10)	H10B—C10—H10C	109.5
C6—C1—S1	117.20 (10)	N1—C11—C13	113.06 (11)
C1—C2—C3	118.74 (13)	N1—C11—C12	112.55 (11)
C1—C2—H2	120.6	C13—C11—C12	112.96 (12)
C3—C2—H2	120.6	N1—C11—H11	105.8
C4—C3—C2	120.30 (13)	C13—C11—H11	105.8
C4—C3—H3	119.8	C12—C11—H11	105.8
C2—C3—H3	119.8	C11—C13—H13A	109.5
C3—C4—C5	120.81 (13)	C11—C13—H13B	109.5
C3—C4—H4	119.6	H13A—C13—H13B	109.5
C5—C4—H4	119.6	C11—C13—H13C	109.5
C4—C5—C6	119.86 (13)	H13A—C13—H13C	109.5
C4—C5—H5	120.1	H13B—C13—H13C	109.5
C6—C5—H5	120.1	C11—C12—H12A	109.5
C5—C6—C1	118.43 (12)	C11—C12—H12B	109.5
C5—C6—C7	121.37 (12)	H12A—C12—H12B	109.5
C1—C6—C7	120.19 (12)	C11—C12—H12C	109.5
O3—C7—C8	123.48 (12)	H12A—C12—H12C	109.5
O3—C7—C6	113.95 (12)	H12B—C12—H12C	109.5
O1—S1—N1—C8	167.45 (9)	C5—C6—C7—O3	20.73 (19)
O2—S1—N1—C8	−62.53 (10)	C1—C6—C7—O3	−159.37 (12)
C1—S1—N1—C8	51.48 (10)	C5—C6—C7—C8	−161.14 (13)
O1—S1—N1—C11	26.69 (11)	C1—C6—C7—C8	18.8 (2)
O2—S1—N1—C11	156.70 (10)	O3—C7—C8—N1	−179.43 (12)
C1—S1—N1—C11	−89.28 (11)	C6—C7—C8—N1	2.6 (2)
O1—S1—C1—C2	31.83 (13)	O3—C7—C8—C9	0.6 (2)
O2—S1—C1—C2	−98.46 (12)	C6—C7—C8—C9	−177.37 (12)
N1—S1—C1—C2	147.76 (11)	C11—N1—C8—C7	102.87 (14)
O1—S1—C1—C6	−149.00 (10)	S1—N1—C8—C7	−41.11 (16)
O2—S1—C1—C6	80.71 (11)	C11—N1—C8—C9	−77.14 (15)
N1—S1—C1—C6	−33.07 (11)	S1—N1—C8—C9	138.88 (11)
C6—C1—C2—C3	−0.5 (2)	C10—O5—C9—O4	−3.37 (19)
S1—C1—C2—C3	178.64 (10)	C10—O5—C9—C8	176.14 (12)
C1—C2—C3—C4	1.1 (2)	C7—C8—C9—O4	−4.9 (2)
C2—C3—C4—C5	−0.9 (2)	N1—C8—C9—O4	175.11 (12)
C3—C4—C5—C6	0.1 (2)	C7—C8—C9—O5	175.59 (12)
C4—C5—C6—C1	0.5 (2)	N1—C8—C9—O5	−4.40 (18)
C4—C5—C6—C7	−179.64 (13)	C8—N1—C11—C13	−80.86 (14)
C2—C1—C6—C5	−0.3 (2)	S1—N1—C11—C13	59.52 (15)
S1—C1—C6—C5	−179.45 (10)	C8—N1—C11—C12	149.66 (12)
C2—C1—C6—C7	179.81 (12)	S1—N1—C11—C12	−69.95 (14)
S1—C1—C6—C7	0.65 (17)

D—H···A	D—H	H···A	D···A	D—H···A
C4—H4···O2i	0.93	2.49	3.311 (2)	147
C3—H3···O2ii	0.93	2.46	3.370 (2)	165
C11—H11···O1iii	0.98	2.39	3.317 (2)	157
O3—H3O···O4	0.88 (2)	1.77 (2)	2.578 (2)	151 (2)

Table 1

Hydrogen-bond geometry (Å, °)

D—H⋯A	D—H	H⋯A	D⋯A	D—H⋯A
C4—H4⋯O2i	0.93	2.49	3.311 (2)	147
C3—H3⋯O2ii	0.93	2.46	3.370 (2)	165
C11—H11⋯O1iii	0.98	2.39	3.317 (2)	157
O3—H3O⋯O4	0.88 (2)	1.77 (2)	2.578 (2)	151 (2)

Symmetry codes: (i) ; (ii) ; (iii) .