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Literature DB >> 21833430

Direct radiolabelling of proteins at cysteine using [18F]-fluorosugars.

Omar Boutureira¹, Gonçalo J L Bernardes, François D'Hooge, Benjamin G Davis.

Abstract

A strategy for the site-specific attachment of 2-deoxy-2-fluorosugars to cysteine and dehydroalanine tagged proteins is reported. When combined with thionation of fluorosugars, such as the widely available (18)F probe 2-deoxy-2-[(18)F]fluoroglucose ([(18)F]FDG), this methodology allows fast and direct access to site-specific [(18)F]FDG-labelled proteins.

Entities: Chemical

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Year: 2011 PMID： 21833430 DOI： 10.1039/c1cc13524d

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

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Cited

9 in total

1. Selective and Reversible Photochemical Derivatization of Cysteine Residues in Peptides and Proteins.

Authors: Selvanathan Arumugam; Jun Guo; Ngalle Eric Mbua; Frédéric Friscourt; Nannan Lin; Emmanuel Nekongo; Geert-Jan Boons; Vladimir V Popik
Journal: Chem Sci Date: 2014-04-01 Impact factor: 9.825

Review 2. ¹⁸ F-Labeling of Sensitive Biomolecules for Positron Emission Tomography.

Authors: Hema S Krishnan; Longle Ma; Neil Vasdev; Steven H Liang
Journal: Chemistry Date: 2017-09-01 Impact factor: 5.236

Review 3. Synthesis and Glycosidation of Anomeric Halides: Evolution from Early Studies to Modern Methods of the 21st Century.

Authors: Yashapal Singh; Scott A Geringer; Alexei V Demchenko
Journal: Chem Rev Date: 2022-06-08 Impact factor: 72.087

Direct radiolabelling of proteins at cysteine using [18F]-fluorosugars.

1. Selective and Reversible Photochemical Derivatization of Cysteine Residues in Peptides and Proteins.

Review 2. ¹⁸ F-Labeling of Sensitive Biomolecules for Positron Emission Tomography.

Review 3. Synthesis and Glycosidation of Anomeric Halides: Evolution from Early Studies to Modern Methods of the 21st Century.

4. Site-Specific Radiofluorination of Biomolecules with 8-[(18)F]-Fluorooctanoic Acid Catalyzed by Lipoic Acid Ligase.

5. A one-pot enzymatic approach to the O-fluoroglucoside of N-methylanthranilate.

6. Synthetically defined glycoprotein vaccines: current status and future directions.

7. Novel [¹⁸F]-labeled thiol for the labeling of Dha- or maleimide-containing biomolecules.

Review 8. Sweetening pharmaceutical radiochemistry by (18)f-fluoroglycosylation: a short review.

9. Probing Site-Selective Conjugation Chemistries for the Construction of Homogeneous Synthetic Glycodendriproteins.

Direct radiolabelling of proteins at cysteine using [18F]-fluorosugars.

1. Selective and Reversible Photochemical Derivatization of Cysteine Residues in Peptides and Proteins.

Review 2. 18 F-Labeling of Sensitive Biomolecules for Positron Emission Tomography.

Review 3. Synthesis and Glycosidation of Anomeric Halides: Evolution from Early Studies to Modern Methods of the 21st Century.

4. Site-Specific Radiofluorination of Biomolecules with 8-[(18)F]-Fluorooctanoic Acid Catalyzed by Lipoic Acid Ligase.

5. A one-pot enzymatic approach to the O-fluoroglucoside of N-methylanthranilate.

6. Synthetically defined glycoprotein vaccines: current status and future directions.

7. Novel [18F]-labeled thiol for the labeling of Dha- or maleimide-containing biomolecules.

Review 8. Sweetening pharmaceutical radiochemistry by (18)f-fluoroglycosylation: a short review.

9. Probing Site-Selective Conjugation Chemistries for the Construction of Homogeneous Synthetic Glycodendriproteins.

Review 2. ¹⁸ F-Labeling of Sensitive Biomolecules for Positron Emission Tomography.

7. Novel [¹⁸F]-labeled thiol for the labeling of Dha- or maleimide-containing biomolecules.