Literature DB >> 21832097

The signal peptide sequence impacts the immune response elicited by a DNA epitope vaccine.

Dimitrios Vatakis1, Minnie McMillan.   

Abstract

We examined the effect of two leader sequences, one from a transmembrane molecule (H2-L(d)) and another from a secreted molecule (rat KC chemokine), on the immunogenicity of DNA epitope vaccines. The chemokine leader enhanced vaccine immunogenicity, thus underscoring the importance of the leader sequence in DNA epitope vaccine design.

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Year:  2011        PMID： 21832097      PMCID： PMC3187025          DOI： 10.1128/CVI.05179-11

Source DB:  PubMed          Journal:  Clin Vaccine Immunol        ISSN： 1556-679X


  43 in total

1.  Quantitative and qualitative analyses of the immune responses induced by a multivalent minigene DNA vaccine.

Authors:  L L An; F Rodriguez; S Harkins; J Zhang; J L Whitton
Journal:  Vaccine       Date:  2000-04-14       Impact factor: 3.641

2.  Humoral immune responses to DNA vaccines expressing secreted, membrane bound and non-secreted forms of the Tania ovis 45W antigen.

Authors:  D R Drew; M Lightowlers; R A Strugnell
Journal:  Vaccine       Date:  2000-05-22       Impact factor: 3.641

Review 3.  DNA vaccines: immunology, application, and optimization*.

Authors:  S Gurunathan; D M Klinman; R A Seder
Journal:  Annu Rev Immunol       Date:  2000       Impact factor: 28.527

4.  Cationic microparticles: A potent delivery system for DNA vaccines.

Authors:  M Singh; M Briones; G Ott; D O'Hagan
Journal:  Proc Natl Acad Sci U S A       Date:  2000-01-18       Impact factor: 11.205

5.  Optimization of epitope processing enhances immunogenicity of multiepitope DNA vaccines.

Authors:  B D Livingston; M Newman; C Crimi; D McKinney; R Chesnut; A Sette
Journal:  Vaccine       Date:  2001-09-14       Impact factor: 3.641

6.  Optimizing the efficacy of epitope-directed DNA vaccination.

Authors:  Monika C Wolkers; Mireille Toebes; Masaru Okabe; John B A G Haanen; Ton N M Schumacher
Journal:  J Immunol       Date:  2002-05-15       Impact factor: 5.422

7.  Efficient priming of CD4+ and CD8+ T cells by DNA vaccination depends on appropriate targeting of sufficient levels of immunologically relevant antigen to appropriate processing pathways.

Authors:  Catherine Rush; Tim Mitchell; Paul Garside
Journal:  J Immunol       Date:  2002-11-01       Impact factor: 5.422

8.  Oral DNA vaccination: antigen uptake and presentation by dendritic cells elicits protective immunity.

Authors:  Björn Cochlovius; Marike J J G Stassar; Marco W Schreurs; Axel Benner; Gosse J Adema
Journal:  Immunol Lett       Date:  2002-02-01       Impact factor: 3.685

9.  Immunization with plasmid DNA encoding MHC class II binding peptide/CLIP-replaced invariant chain (Ii) induces specific helper T cells in vivo: the assessment of Ii p31 and p41 isoforms as vehicles for immunization.

Authors:  T Nagata; T Higashi; T Aoshi; M Suzuki; M Uchijima; Y Koide
Journal:  Vaccine       Date:  2001-10-12       Impact factor: 3.641

10.  CD4(+) T cells induced by a DNA vaccine: immunological consequences of epitope-specific lysosomal targeting.

Authors:  F Rodriguez; S Harkins; J M Redwine; J M de Pereda; J L Whitton
Journal:  J Virol       Date:  2001-11       Impact factor: 5.103
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  2 in total

1.  Naturally acquired antibody kinetics against Plasmodium vivax antigens in people from a low malaria transmission region in western Thailand.

Authors:  Ivo Mueller; Rhea J Longley; Zoe Shih-Jung Liu; Jetsumon Sattabongkot; Michael White; Sadudee Chotirat; Chalermpon Kumpitak; Eizo Takashima; Matthias Harbers; Wai-Hong Tham; Julie Healer; Chetan E Chitnis; Takafumi Tsuboi
Journal:  BMC Med       Date:  2022-03-09       Impact factor: 11.150

2.  Protective Immunity to Dengue Virus Induced by DNA Vaccines Encoding Nonstructural Proteins in a Lethal Challenge Immunocompetent Mouse Model.

Authors:  Rúbens Prince Dos Santos Alves; Robert Andreata-Santos; Carla Longo de Freitas; Lennon Ramos Pereira; Denicar Lina Nascimento Fabris-Maeda; Mônica Josiane Rodrigues-Jesus; Samuel Santos Pereira; Alexia Adrianne Venceslau Brito Carvalho; Natiely Silva Sales; Jean Pierre Schatzmann Peron; Jaime Henrique Amorim; Luís Carlos de Souza Ferreira
Journal:  Front Med Technol       Date:  2020-10-30
  2 in total

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