Literature DB >> 2182912

Removal of cryptic poxvirus transcription termination signals from the human immunodeficiency virus type 1 envelope gene enhances expression and immunogenicity of a recombinant vaccinia virus.

P L Earl1, A W Hügin, B Moss.   

Abstract

The in vivo role of the proposed poxvirus early transcription termination signal TTTTTNT was confirmed by analysis of the RNA species made by recombinant vaccinia viruses. Premature transcription termination occurred following each of two TTTTTNT sequences present naturally within the coding region of the human immunodeficiency virus type 1 envelope gene. Alteration of the TTTTTNT sequences, without changing the encoded amino acids, resulted in production of full-length early mRNAs, improved protein expression, and a more consistent immune response.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 2182912      PMCID： PMC249414          DOI： 10.1128/JVI.64.5.2448-2451.1990

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  33 in total

1.  Complete nucleotide sequence of the AIDS virus, HTLV-III.

Authors:  L Ratner; W Haseltine; R Patarca; K J Livak; B Starcich; S F Josephs; E R Doran; J A Rafalski; E A Whitehorn; K Baumeister
Journal:  Nature       Date:  1985 Jan 24-30       Impact factor: 49.962

2.  In vitro mutagenesis of the promoter region for a vaccinia virus gene: evidence for tandem early and late regulatory signals.

Authors:  M A Cochran; C Puckett; B Moss
Journal:  J Virol       Date:  1985-04       Impact factor: 5.103

3.  Primary structure of the vesicular stomatitis virus polymerase (L) gene: evidence for a high frequency of mutations.

Authors:  M Schubert; G G Harmison; E Meier
Journal:  J Virol       Date:  1984-08       Impact factor: 5.103

4.  Nucleotide sequence of the gene encoding the fusion (F) glycoprotein of human respiratory syncytial virus.

Authors:  P L Collins; Y T Huang; G W Wertz
Journal:  Proc Natl Acad Sci U S A       Date:  1984-12       Impact factor: 11.205

5.  Extension of the transcriptional and translational map of the left end of the vaccinia virus genome to 21 kilobase pairs.

Authors:  J A Cooper; R Wittek; B Moss
Journal:  J Virol       Date:  1981-09       Impact factor: 5.103

6.  Arrangement of late RNAs transcribed from a 7.1-kilobase EcoRI vaccinia virus DNA fragment.

Authors:  A Mahr; B E Roberts
Journal:  J Virol       Date:  1984-02       Impact factor: 5.103

7.  Correct sequence for the major nucleocapsid protein mRNA of respiratory syncytial virus.

Authors:  P L Collins; K Anderson; S J Langer; G W Wertz
Journal:  Virology       Date:  1985-10-15       Impact factor: 3.616

8.  Nucleotide sequence of the gene coding for the major protein of hepatitis B virus surface antigen.

Authors:  P Valenzuela; P Gray; M Quiroga; J Zaldivar; H M Goodman; W J Rutter
Journal:  Nature       Date:  1979-08-30       Impact factor: 49.962

9.  Evolution of vesicular stomatitis virus in athymic nude mice: mutations associated with natural killer cell selection.

Authors:  S B Vandepol; J J Holland
Journal:  J Gen Virol       Date:  1986-03       Impact factor: 3.891

10.  General method for production and selection of infectious vaccinia virus recombinants expressing foreign genes.

Authors:  M Mackett; G L Smith; B Moss
Journal:  J Virol       Date:  1984-03       Impact factor: 5.103
View more
  78 in total

1.  Recombinant vaccinia viruses. Design, generation, and isolation.

Authors:  C C Broder; P L Earl
Journal:  Mol Biotechnol       Date:  1999-12-15       Impact factor: 2.695

2.  High-affinity T helper epitope induces complementary helper and APC polarization, increased CTL, and protection against viral infection.

Authors:  J D Ahlers; I M Belyakov; E K Thomas; J A Berzofsky
Journal:  J Clin Invest       Date:  2001-12       Impact factor: 14.808

3.  Coadministration of HIV vaccine vectors with vaccinia viruses expressing IL-15 but not IL-2 induces long-lasting cellular immunity.

Authors:  SangKon Oh; Jay A Berzofsky; Donald S Burke; Thomas A Waldmann; Liyanage P Perera
Journal:  Proc Natl Acad Sci U S A       Date:  2003-03-07       Impact factor: 11.205

4.  A push-pull approach to maximize vaccine efficacy: abrogating suppression with an IL-13 inhibitor while augmenting help with granulocyte/macrophage colony-stimulating factor and CD40L.

Authors:  Jeffrey D Ahlers; Igor M Belyakov; Masaki Terabe; Rima Koka; Debra D Donaldson; Elaine K Thomas; Jay A Berzofsky
Journal:  Proc Natl Acad Sci U S A       Date:  2002-09-13       Impact factor: 11.205

5.  IL-15/IL-15Ralpha-mediated avidity maturation of memory CD8+ T cells.

Authors:  SangKon Oh; Liyanage P Perera; Donald S Burke; Thomas A Waldmann; Jay A Berzofsky
Journal:  Proc Natl Acad Sci U S A       Date:  2004-10-11       Impact factor: 11.205

6.  Simultaneous high-resolution analysis of vaccinia virus and host cell transcriptomes by deep RNA sequencing.

Authors:  Zhilong Yang; Daniel P Bruno; Craig A Martens; Stephen F Porcella; Bernard Moss
Journal:  Proc Natl Acad Sci U S A       Date:  2010-06-07       Impact factor: 11.205

7.  Viral double-stranded RNAs from vaccinia virus early or intermediate gene transcripts possess PKR activating function, resulting in NF-kappaB activation, when the K1 protein is absent or mutated.

Authors:  Kristen L Willis; Jeffrey O Langland; Joanna L Shisler
Journal:  J Biol Chem       Date:  2010-12-23       Impact factor: 5.157

8.  Intercellular transfer of a glycosylphosphatidylinositol (GPI)-linked protein: release and uptake of CD4-GPI from recombinant adeno-associated virus-transduced HeLa cells.

Authors:  S M Anderson; G Yu; M Giattina; J L Miller
Journal:  Proc Natl Acad Sci U S A       Date:  1996-06-11       Impact factor: 11.205

9.  Human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus env proteins possess a functionally conserved assembly domain.

Authors:  R W Doms; P L Earl; S Chakrabarti; B Moss
Journal:  J Virol       Date:  1990-07       Impact factor: 5.103

Review 10.  Reflections on the early development of poxvirus vectors.

Authors:  Bernard Moss
Journal:  Vaccine       Date:  2013-04-10       Impact factor: 3.641
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.