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Literature DB >> 21828266

A snRNP's ordered path to maturity.

Abstract

The U5 snRNP (small ribonucleoprotein) contains several functionally crucial splicing factors that form an extensive interaction network both in the snRNP and within the spliceosome. In this issue of Genes & Development, Weber and colleagues (pp. 1601-1612) shed light on the dynamic assembly of this critical spliceosomal component and elucidate the molecular interactions underlying the ordered addition of Brr2, a pivotal spliceosomal helicase, to the U5 snRNP.

Entities: Chemical Gene

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Year: 2011 PMID： 21828266 PMCID： PMC3182023 DOI： 10.1101/gad.17311211

Source DB: PubMed Journal: Genes Dev ISSN： 0890-9369 Impact factor: 11.361

30 in total

1. Distinct domains of splicing factor Prp8 mediate different aspects of spliceosome activation.

Authors: Andreas N Kuhn; Elizabeth M Reichl; David A Brow
Journal: Proc Natl Acad Sci U S A Date: 2002-06-26 Impact factor: 11.205

2. Ubiquitin binding by a variant Jab1/MPN domain in the essential pre-mRNA splicing factor Prp8p.

Authors: Priya Bellare; Alan K Kutach; Amy K Rines; Christine Guthrie; Erik J Sontheimer
Journal: RNA Date: 2006-02 Impact factor: 4.942

Review 3. Multiple genetic and biochemical interactions of Brr2, Prp8, Prp31, Prp1 and Prp4 kinase suggest a function in the control of the activation of spliceosomes in Schizosaccharomyces pombe.

Authors: Claudia A Bottner; Henning Schmidt; Sven Vogel; Melanie Michele; Norbert F Käufer
Journal: Curr Genet Date: 2005-10-12 Impact factor: 3.886

4. Mechanism for Aar2p function as a U5 snRNP assembly factor.

Authors: Gert Weber; Vanessa F Cristão; Flavia de L Alves; Karine F Santos; Nicole Holton; Juri Rappsilber; Jean D Beggs; Markus C Wahl
Journal: Genes Dev Date: 2011-07-15 Impact factor: 11.361

5. Biochemical and genetic analyses of the U5, U6, and U4/U6 x U5 small nuclear ribonucleoproteins from Saccharomyces cerevisiae.

Authors: S W Stevens; I Barta; H Y Ge; R E Moore; M K Young; T D Lee; J Abelson
Journal: RNA Date: 2001-11 Impact factor: 4.942

6. The yeast U5 snRNP coisolated with the U1 snRNP has an unexpected protein composition and includes the splicing factor Aar2p.

Authors: A Gottschalk; B Kastner; R Lührmann; P Fabrizio
Journal: RNA Date: 2001-11 Impact factor: 4.942

7. Functional contacts with a range of splicing proteins suggest a central role for Brr2p in the dynamic control of the order of events in spliceosomes of Saccharomyces cerevisiae.

Authors: R W van Nues; J D Beggs
Journal: Genetics Date: 2001-04 Impact factor: 4.562

A snRNP's ordered path to maturity.

1. Distinct domains of splicing factor Prp8 mediate different aspects of spliceosome activation.

2. Ubiquitin binding by a variant Jab1/MPN domain in the essential pre-mRNA splicing factor Prp8p.

Review 3. Multiple genetic and biochemical interactions of Brr2, Prp8, Prp31, Prp1 and Prp4 kinase suggest a function in the control of the activation of spliceosomes in Schizosaccharomyces pombe.

4. Mechanism for Aar2p function as a U5 snRNP assembly factor.

5. Biochemical and genetic analyses of the U5, U6, and U4/U6 x U5 small nuclear ribonucleoproteins from Saccharomyces cerevisiae.

6. The yeast U5 snRNP coisolated with the U1 snRNP has an unexpected protein composition and includes the splicing factor Aar2p.

7. Functional contacts with a range of splicing proteins suggest a central role for Brr2p in the dynamic control of the order of events in spliceosomes of Saccharomyces cerevisiae.

Review 8. Prp8 protein: at the heart of the spliceosome.

9. The first ATPase domain of the yeast 246-kDa protein is required for in vivo unwinding of the U4/U6 duplex.

10. Prp8p dissection reveals domain structure and protein interaction sites.

1. Recruitment of the NineTeen Complex to the activated spliceosome requires AtPRMT5.