Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Return to youth with Sox17.

Literature DB >> 21828265

Return to youth with Sox17.

Abstract

Maturation of hematopoietic stem cells (HSCs) from fetal to adult state and differentiation to progenitors are thought to follow a one-way street. In this issue of Genes & Development, He and colleagues (pp. 1613-1627) show that overexpression of Sox17 can convert adult multipotential progenitors to self-renewing HSCs that possess fetal properties. These findings challenge the irreversibility of hematopoietic development, and open up new perspectives to understand the different forms of HSC self-renewal at distinct stages of ontogeny and during transformation.

Entities: Chemical Gene

Mesh：

Substances：

Year: 2011 PMID： 21828265 PMCID： PMC3182022 DOI： 10.1101/gad.17328611

Source DB: PubMed Journal: Genes Dev ISSN： 0890-9369 Impact factor: 11.361

39 in total

1. HOXB4-induced expansion of adult hematopoietic stem cells ex vivo.

Authors: Jennifer Antonchuk; Guy Sauvageau; R Keith Humphries
Journal: Cell Date: 2002-04-05 Impact factor: 41.582

2. Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene.

Authors: Hanna K A Mikkola; Jenny Klintman; Haidi Yang; Hanno Hock; Thorsten M Schlaeger; Yuko Fujiwara; Stuart H Orkin
Journal: Nature Date: 2003-01-19 Impact factor: 49.962

Review 3. The journey of developing hematopoietic stem cells.

Authors: Hanna K A Mikkola; Stuart H Orkin
Journal: Development Date: 2006-10 Impact factor: 6.868

4. Identification of a new intrinsically timed developmental checkpoint that reprograms key hematopoietic stem cell properties.

Authors: Michelle B Bowie; David G Kent; Brad Dykstra; Kristen D McKnight; Lindsay McCaffrey; Pamela A Hoodless; Connie J Eaves
Journal: Proc Natl Acad Sci U S A Date: 2007-03-22 Impact factor: 11.205

Review 5. Transcriptional activators, repressors, and epigenetic modifiers controlling hematopoietic stem cell development.

Authors: Michael A Teitell; Hanna K A Mikkola
Journal: Pediatr Res Date: 2006-04 Impact factor: 3.756

6. Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells.

Authors: Injune Kim; Thomas L Saunders; Sean J Morrison
Journal: Cell Date: 2007-07-26 Impact factor: 41.582

7. Hematopoietic stem cells proliferate until after birth and show a reversible phase-specific engraftment defect.

Authors: Michelle B Bowie; Kristen D McKnight; David G Kent; Lindsay McCaffrey; Pamela A Hoodless; Connie J Eaves
Journal: J Clin Invest Date: 2006-10 Impact factor: 14.808

8. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

Authors: Kazutoshi Takahashi; Shinya Yamanaka
Journal: Cell Date: 2006-08-10 Impact factor: 41.582

9. HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors.

Authors: Michael Kyba; Rita C R Perlingeiro; George Q Daley
Journal: Cell Date: 2002-04-05 Impact factor: 41.582

10. Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates.

Authors: Emmanuelle Passegué; Amy J Wagers; Sylvie Giuriato; Wade C Anderson; Irving L Weissman
Journal: J Exp Med Date: 2005-12-05 Impact factor: 14.307

3 in total