OBJECTIVE: Healthy obese phenotype with favorable metabolic profiles is proposed. However, whether healthy obesity leads to target organ changes is controversial. We investigated the impact of a healthy obesity on cardiovascular structure and function. METHODS: A total of 2540 participants without known cardiovascular disease were enrolled. According to BMI and the metabolic syndrome (MetS) component, the participants were divided into six groups: healthy (none of five MetS components) normal weight (BMI <23 kg/m²), unhealthy (one or more of five MetS components) normal weight, healthy overweight (BMI 23-24.9 kg/m²), unhealthy overweight, healthy obesity (BMI ≥25 kg/m²), and unhealthy obesity. The cardiovascular changes were assessed by echocardiography, tissue Doppler imaging (TDI), carotid ultrasonography, and pulse wave velocity (PWV). RESULTS: In a multivariate analysis after adjusting for age, sex, heart rate, high-sensitivity C-reactive protein, and medication for hypertension and diabetes mellitus, the unhealthy overweight and obese groups showed statistically significant changes in the left ventricular mass index, mitral E/A ratio, E/Ea ratio, TDI Ea velocity, common carotid artery intima-media thickness (CCA-IMT), and brachial-ankle PWV (P < 0.001), compared with the healthy normal weight individuals. In the healthy overweight and obese groups, CCA-IMT and brachial-ankle PWV values were similar, but left-ventricular mass index and TDI Ea velocity were significantly different (P < 0.001). CONCLUSION: Healthy obesity was associated with subtle changes in left ventricular structure and function. These data provide evidence that metabolically healthy phenotypes with excess weight may not be a benign condition.
OBJECTIVE: Healthy obese phenotype with favorable metabolic profiles is proposed. However, whether healthy obesity leads to target organ changes is controversial. We investigated the impact of a healthy obesity on cardiovascular structure and function. METHODS: A total of 2540 participants without known cardiovascular disease were enrolled. According to BMI and the metabolic syndrome (MetS) component, the participants were divided into six groups: healthy (none of five MetS components) normal weight (BMI <23 kg/m²), unhealthy (one or more of five MetS components) normal weight, healthy overweight (BMI 23-24.9 kg/m²), unhealthy overweight, healthy obesity (BMI ≥25 kg/m²), and unhealthy obesity. The cardiovascular changes were assessed by echocardiography, tissue Doppler imaging (TDI), carotid ultrasonography, and pulse wave velocity (PWV). RESULTS: In a multivariate analysis after adjusting for age, sex, heart rate, high-sensitivity C-reactive protein, and medication for hypertension and diabetes mellitus, the unhealthy overweight and obese groups showed statistically significant changes in the left ventricular mass index, mitral E/A ratio, E/Ea ratio, TDI Ea velocity, common carotid artery intima-media thickness (CCA-IMT), and brachial-ankle PWV (P < 0.001), compared with the healthy normal weight individuals. In the healthy overweight and obese groups, CCA-IMT and brachial-ankle PWV values were similar, but left-ventricular mass index and TDI Ea velocity were significantly different (P < 0.001). CONCLUSION:Healthy obesity was associated with subtle changes in left ventricular structure and function. These data provide evidence that metabolically healthy phenotypes with excess weight may not be a benign condition.
Authors: Zhiqian Gao; Philip R Khoury; Connie E McCoy; Amy S Shah; Thomas R Kimball; Lawrence M Dolan; Elaine M Urbina Journal: Atherosclerosis Date: 2015-12-08 Impact factor: 5.162
Authors: S Popa; M Moţa; A Popa; E Moţa; C Serafinceanu; C Guja; D Catrinoiu; N Hâncu; R Lichiardopol; C Bala; A Popa; G Roman; G Radulian; R Timar; B Mihai Journal: J Endocrinol Invest Date: 2016-04-28 Impact factor: 4.256
Authors: Xanthia F Samaropoulos; Kristen G Hairston; Andrea Anderson; Steven M Haffner; Carlos Lorenzo; Maria Montez; Jill M Norris; Ann L Scherzinger; Yii-Der Ida Chen; Lynne E Wagenknecht Journal: Obesity (Silver Spring) Date: 2013-05-29 Impact factor: 5.002
Authors: Kimberly M Jeckel; D N Rao Veeramachaneni; Adam J Chicco; Phillip L Chapman; Christopher M Mulligan; Jennifer R Hegarty; Michael J Pagliassotti; Lindsay A Ferguson; Gerrit J Bouma; Melinda A Frye Journal: PLoS One Date: 2012-12-26 Impact factor: 3.240