OBJECTIVE: The STISIM driving simulator is widely used. To enhance its usefulness in pharmacological research, a calibration study was performed to test a standardized highway driving test scenario after administration of three different dosages of alcohol and placebo. METHODS:Twenty-seven healthy young adults (14 men and 13 women; mean age (SD) = 22.8 (1.4)) participated in this randomized, single-blind crossover trial. Subjects received alcohol to gain a blood alcohol concentration (BAC) of 0.05%, 0.08%, and 0.11%, or placebo-alcohol. In each condition, subjects completed a 100-km highway driving simulator test. The standard deviation of lateral position, the weaving of the car, was the primary parameter of the test. RESULTS:Alcohol produced dose-dependent driving impairment. Standard deviation of lateral position and standard deviation of speed were significantly increased relative to placebo (p < 0.05). Subjective driving assessments were in line with the objective driving measurements. CONCLUSION: The STISIM highway driving simulator test is able to differentiate dose-dependent impairment after administration of alcohol. The highway driving test scenario is suitable for future psychopharmacological research.
RCT Entities:
OBJECTIVE: The STISIM driving simulator is widely used. To enhance its usefulness in pharmacological research, a calibration study was performed to test a standardized highway driving test scenario after administration of three different dosages of alcohol and placebo. METHODS: Twenty-seven healthy young adults (14 men and 13 women; mean age (SD) = 22.8 (1.4)) participated in this randomized, single-blind crossover trial. Subjects received alcohol to gain a blood alcohol concentration (BAC) of 0.05%, 0.08%, and 0.11%, or placebo-alcohol. In each condition, subjects completed a 100-km highway driving simulator test. The standard deviation of lateral position, the weaving of the car, was the primary parameter of the test. RESULTS:Alcohol produced dose-dependent driving impairment. Standard deviation of lateral position and standard deviation of speed were significantly increased relative to placebo (p < 0.05). Subjective driving assessments were in line with the objective driving measurements. CONCLUSION: The STISIM highway driving simulator test is able to differentiate dose-dependent impairment after administration of alcohol. The highway driving test scenario is suitable for future psychopharmacological research.
Authors: Joris C Verster; Adriana C Bervoets; Suzanne de Klerk; Rick A Vreman; Berend Olivier; Thomas Roth; Karel A Brookhuis Journal: Psychopharmacology (Berl) Date: 2014-02-22 Impact factor: 4.530
Authors: Joris C Verster; Chris Alford; Adriana C Bervoets; Suzanne de Klerk; James A Grange; Anna Hogewoning; Kate Jones; Darren L Kruisselbrink; Lauren Owen; Thomas M Piasecki; Senta Jorinde Raasveld; Sam Royle; Wendy S Slutske; Gordon S Smith; Richard Stephens Journal: Curr Drug Abuse Rev Date: 2013-09
Authors: Monique M Cherrier; Danny D Shen; Laura Shireman; Andrew J Saxon; Tracy Simpson; Alex Men; Preetma Kooner; Gregory W Terman Journal: Pharmacol Biochem Behav Date: 2021-11-04 Impact factor: 3.533
Authors: Julianne L Price; Ben Lewis; Jeff Boissoneault; Ian R Frazier; Sara Jo Nixon Journal: Psychopharmacology (Berl) Date: 2017-12-06 Impact factor: 4.530