| Literature DB >> 21822264 |
Meng Li1, Hong Zhao, Xiaosong Zhang, Laura D Wood, Robert A Anders, Michael A Choti, Timothy M Pawlik, Hubert D Daniel, Rajesh Kannangai, G Johan A Offerhaus, Victor E Velculescu, Linfang Wang, Shibin Zhou, Bert Vogelstein, Ralph H Hruban, Nick Papadopoulos, Jianqiang Cai, Michael S Torbenson, Kenneth W Kinzler.
Abstract
Through exomic sequencing of ten hepatitis C virus (HCV)-associated hepatocellular carcinomas (HCC) and subsequent evaluation of additional affected individuals, we discovered novel inactivating mutations of ARID2 in four major subtypes of HCC (HCV-associated HCC, hepatitis B virus (HBV)-associated HCC, alcohol-associated HCC and HCC with no known etiology). Notably, 18.2% of individuals with HCV-associated HCC in the United States and Europe harbored ARID2 inactivation mutations, suggesting that ARID2 is a tumor suppressor gene that is relatively commonly mutated in this tumor subtype.Entities:
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Year: 2011 PMID： 21822264 PMCID： PMC3163746 DOI： 10.1038/ng.903
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330