J H Meurman1, A Bascones-Martinez. 1. Institute of Dentistry, University of Helsinki, Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Helsinki, Finland. jukka.meurman@helsinki.fi
Abstract
OBJECTIVE: Infection and inflammation play a role in carcinogenesis, and highly prevalent oral and dental diseases have been significantly linked to some types of cancer. This article reviews current literature in this area. MATERIALS AND METHODS: Open literature review using the PubMed database and focused on publications from 2000 to 2010. RESULTS: Numerous potential mechanisms are implicated in the oral disease/carcinogenesis paradigm, including infection- and inflammation-associated cell pathology and microbial carcinogen metabolism. Poor oral hygiene is associated with oral cancer, but there is also evidence of a possible link between oral or dental infections and malignancies in general. CONCLUSION: Oral infections may trigger malignant transformation in tissues of the mouth and other organs. However, scientific evidence to date remains weak and further well-conducted studies are warranted before cancer can be properly added to the list of oral infection-related systemic diseases.
OBJECTIVE: Infection and inflammation play a role in carcinogenesis, and highly prevalent oral and dental diseases have been significantly linked to some types of cancer. This article reviews current literature in this area. MATERIALS AND METHODS: Open literature review using the PubMed database and focused on publications from 2000 to 2010. RESULTS: Numerous potential mechanisms are implicated in the oral disease/carcinogenesis paradigm, including infection- and inflammation-associated cell pathology and microbial carcinogen metabolism. Poor oral hygiene is associated with oral cancer, but there is also evidence of a possible link between oral or dental infections and malignancies in general. CONCLUSION:Oral infections may trigger malignant transformation in tissues of the mouth and other organs. However, scientific evidence to date remains weak and further well-conducted studies are warranted before cancer can be properly added to the list of oral infection-related systemic diseases.
Authors: Jinchun Sun; Jinshan Jin; Richard D Beger; Carl E Cerniglia; Maocheng Yang; Huizhong Chen Journal: Toxicol In Vitro Date: 2016-07-30 Impact factor: 3.500
Authors: Jukka H Meurman; Håkan Källmén; Leif C Andersson; Tulay Yucel-Lindberg; Birgitta Söder Journal: PLoS One Date: 2022-10-21 Impact factor: 3.752
Authors: C P Furquim; G M S Soares; L L Ribeiro; M A Azcarate-Peril; N Butz; J Roach; K Moss; C Bonfim; C C Torres-Pereira; F R F Teles Journal: J Dent Res Date: 2016-11-13 Impact factor: 6.116
Authors: D Nasrollahzadeh; R Malekzadeh; K Aghcheli; M Sotoudeh; S Merat; F Islami; F Kamangar; C C Abnet; R Shakeri; A Pourshams; S Semnani; P Boffetta; S M Dawsey; W Ye Journal: Br J Cancer Date: 2012-07-19 Impact factor: 7.640