Literature DB >> 21816179

Behavioural deficits associated with maternal immune activation in the rat model of schizophrenia.

Amy R Wolff1, Kirsten R Cheyne, David K Bilkey.   

Abstract

Schizophrenia is associated with changes in memory and contextual processing. As maternal infection is a risk factor in schizophrenia we tested for these impairments in a maternal immune activation (MIA) animal model. MIA rats displayed impaired object recognition memory, despite intact object discrimination, and a reduced reinstatement of rearing in response to a contextual manipulation. These results link MIA to contextual impairments in schizophrenia, possibly through changes in hippocampal function.
Copyright © 2011 Elsevier B.V. All rights reserved.

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Year:  2011        PMID： 21816179     DOI： 10.1016/j.bbr.2011.07.033

Source DB:  PubMed          Journal:  Behav Brain Res        ISSN： 0166-4328            Impact factor:   3.332


  20 in total

1.  Prenatal immune challenge in rats: altered responses to dopaminergic and glutamatergic agents, prepulse inhibition of acoustic startle, and reduced route-based learning as a function of maternal body weight gain after prenatal exposure to poly IC.

Authors:  Charles V Vorhees; Devon L Graham; Amanda A Braun; Tori L Schaefer; Matthew R Skelton; Neil M Richtand; Michael T Williams
Journal:  Synapse       Date:  2012-05-15       Impact factor: 2.562

2.  Variability in PolyIC induced immune response: Implications for preclinical maternal immune activation models.

Authors:  Milo Careaga; Sandra L Taylor; Carolyn Chang; Alex Chiang; Katherine M Ku; Robert F Berman; Judy A Van de Water; Melissa D Bauman
Journal:  J Neuroimmunol       Date:  2018-06-28       Impact factor: 3.478

Review 3.  Maternal Immune Activation and Autism Spectrum Disorder: From Rodents to Nonhuman and Human Primates.

Authors:  Milo Careaga; Takeshi Murai; Melissa D Bauman
Journal:  Biol Psychiatry       Date:  2016-10-25       Impact factor: 13.382

4.  Prenatal immune challenge in rats: effects of polyinosinic-polycytidylic acid on spatial learning, prepulse inhibition, conditioned fear, and responses to MK-801 and amphetamine.

Authors:  Charles V Vorhees; Devon L Graham; Amanda A Braun; Tori L Schaefer; Matthew R Skelton; Neil M Richtand; Michael T Williams
Journal:  Neurotoxicol Teratol       Date:  2014-11-08       Impact factor: 3.763

5.  Improved Social Interaction, Recognition and Working Memory with Cannabidiol Treatment in a Prenatal Infection (poly I:C) Rat Model.

Authors:  Ashleigh L Osborne; Nadia Solowij; Ilijana Babic; Xu-Feng Huang; Katrina Weston-Green
Journal:  Neuropsychopharmacology       Date:  2017-02-23       Impact factor: 7.853

6.  Infection of the murine placenta by Listeria monocytogenes induces sex-specific responses in the fetal brain.

Authors:  Kun Ho Lee; Matti Kiupel; Thomas Woods; Prachee Pingle; Jonathan Hardy
Journal:  Pediatr Res       Date:  2022-09-20       Impact factor: 3.953

7.  Aberrant Phase Precession of Lateral Septal Cells in a Maternal Immune Activation Model of Schizophrenia Risk May Disrupt the Integration of Location with Reward.

Authors:  Lucinda J Speers; Robert Schmidt; David K Bilkey
Journal:  J Neurosci       Date:  2022-04-08       Impact factor: 6.709

Review 8.  Evidence for a dysregulated immune system in the etiology of psychiatric disorders.

Authors:  Sinead M Gibney; Hemmo A Drexhage
Journal:  J Neuroimmune Pharmacol       Date:  2013-05-05       Impact factor: 4.147

Review 9.  Aberrant neural synchrony in the maternal immune activation model: using translatable measures to explore targeted interventions.

Authors:  Desiree D Dickerson; David K Bilkey
Journal:  Front Behav Neurosci       Date:  2013-12-27       Impact factor: 3.558

10.  Hippocampal Sequencing Mechanisms Are Disrupted in a Maternal Immune Activation Model of Schizophrenia Risk.

Authors:  Lucinda J Speers; Kirsten R Cheyne; Elena Cavani; Tara Hayward; Robert Schmidt; David K Bilkey
Journal:  J Neurosci       Date:  2021-07-12       Impact factor: 6.167
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