BACKGROUND: To determine a possible relation between Mycoplasma pneumoniae (MP) or Chlamidia pneumoniae (CP) seropositivity and age-related macular degeneration (AMD). METHODS: Sixty patients (20 wet AMD, 20 dry AMD and 20 non-AMD controls) were included in the study. Serum samples were collected for analysis of IgM and IgG antibody seropositivity for CP and MP by enzyme-linked immunosorbent assay (ELISA). Comparison of the distribution of seropositivity of these antibodies among patients with wet and dry AMD, and controls was performed. A prospective comparative clinical trial was applied. RESULTS: There was no major difference in the distribution of IgM and IgG seropositivity to CP and MP in patients with wet and dry AMD, and in controls (p > 0.05). CONCLUSIONS: We found no significant association between MP as well as CP antibody titers and AMD. It seems that MP or CP infection is not a risk factor for AMD. KEYWORDS: Mycoplasma pneumoniae; Chlamydia pneumoniae; Age-related macular degeneration; Serology.
BACKGROUND: To determine a possible relation between Mycoplasma pneumoniae (MP) or Chlamidia pneumoniae (CP) seropositivity and age-related macular degeneration (AMD). METHODS: Sixty patients (20 wet AMD, 20 dry AMD and 20 non-AMD controls) were included in the study. Serum samples were collected for analysis of IgM and IgG antibody seropositivity for CP and MP by enzyme-linked immunosorbent assay (ELISA). Comparison of the distribution of seropositivity of these antibodies among patients with wet and dry AMD, and controls was performed. A prospective comparative clinical trial was applied. RESULTS: There was no major difference in the distribution of IgM and IgG seropositivity to CP and MP in patients with wet and dry AMD, and in controls (p > 0.05). CONCLUSIONS: We found no significant association between MP as well as CP antibody titers and AMD. It seems that MP or CP infection is not a risk factor for AMD. KEYWORDS: Mycoplasma pneumoniae; Chlamydia pneumoniae; Age-related macular degeneration; Serology.
Authors: Luba Robman; Olaimatu S Mahdi; Jie Jin Wang; George Burlutsky; Paul Mitchell; Gerald Byrne; Robyn Guymer; Hugh Taylor Journal: Invest Ophthalmol Vis Sci Date: 2007-09 Impact factor: 4.799
Authors: Daniel M Miller; Diego G Espinosa-Heidmann; Jessica Legra; Sander R Dubovy; Ivan J Sũner; Daniel D Sedmak; Richard D Dix; Scott W Cousins Journal: Am J Ophthalmol Date: 2004-09 Impact factor: 5.258