PURPOSE: Hemorrhagic metastatic brain tumors are not rare, but little is known about the surgical outcome following treatment. We conducted this study to determine the result of the surgical outcome of hemorrhagic metastatic brain tumors. MATERIALS AND METHODS: From July 2001 to December 2008, 21 patients underwent surgery for hemorrhagic metastatic brain tumors at our institution. 15 patients had lung cancer, 3 had hepatocellular carcinoma, and the rest had rectal cancer, renal cell carcinoma, and sarcoma. 20 patients had macroscopic hemorrhage in the tumors, and one patient had intracerebral hemorrhage surrounding the tumor. A retrospective clinical review was conducted focusing on the patterns of presenting symptoms and signs, as well as local recurrence following surgery. RESULTS: Among 21 hemorrhagic brain metastases, local recurrence developed in two patients. The 12 month progression free survival rate was 86.1%. Mean time to progression was 20.8 months and median survival time after surgery was 11.7 months. CONCLUSION: The results of our study showed that hemorrhagic metastatic brain tumors rarely recurred after surgery. Surgery should be considered as a good treatment option for hemorrhagic brain metastasis, especially in cases with increased intracranial pressure or severe neurologic deficits.
PURPOSE:Hemorrhagic metastatic brain tumors are not rare, but little is known about the surgical outcome following treatment. We conducted this study to determine the result of the surgical outcome of hemorrhagic metastatic brain tumors. MATERIALS AND METHODS: From July 2001 to December 2008, 21 patients underwent surgery for hemorrhagic metastatic brain tumors at our institution. 15 patients had lung cancer, 3 had hepatocellular carcinoma, and the rest had rectal cancer, renal cell carcinoma, and sarcoma. 20 patients had macroscopic hemorrhage in the tumors, and one patient had intracerebral hemorrhage surrounding the tumor. A retrospective clinical review was conducted focusing on the patterns of presenting symptoms and signs, as well as local recurrence following surgery. RESULTS: Among 21 hemorrhagic brain metastases, local recurrence developed in two patients. The 12 month progression free survival rate was 86.1%. Mean time to progression was 20.8 months and median survival time after surgery was 11.7 months. CONCLUSION: The results of our study showed that hemorrhagic metastatic brain tumors rarely recurred after surgery. Surgery should be considered as a good treatment option for hemorrhagic brain metastasis, especially in cases with increased intracranial pressure or severe neurologic deficits.
Entities:
Keywords:
Brain; Hemorrhage; Local neoplasm recurrences; Neoplasm metastasis; Surgery
Authors: S D Lavine; Z Petrovich; A A Cohen-Gadol; L S Masri; D L Morton; S J O'Day; R Essner; V Zelman; C Yu; G Luxton; M L Apuzzo Journal: Neurosurgery Date: 1999-01 Impact factor: 4.654
Authors: D Kondziolka; M Bernstein; L Resch; C H Tator; J F Fleming; R G Vanderlinden; H Schutz Journal: J Neurosurg Date: 1987-12 Impact factor: 5.115
Authors: Heon Yoo; Young Zoon Kim; Byung Ho Nam; Sang Hoon Shin; Hee Seok Yang; Jin Soo Lee; Jae Il Zo; Seung Hoon Lee Journal: J Neurosurg Date: 2009-04 Impact factor: 5.115
Authors: Kristine Bauer-Nilsen; Daniel M Trifiletti; Ajay Chatrath; Henry Ruiz-Garcia; Eduardo Marchan; Jennifer Peterson; Byron C May; Jason P Sheehan Journal: J Neurooncol Date: 2018-06-20 Impact factor: 4.130
Authors: Yuanxuan Xia; Leila A Mashouf; Russell Maxwell; Luke C Peng; Evan J Lipson; William H Sharfman; Chetan Bettegowda; Kristin J Redmond; Lawrence R Kleinberg; Michael Lim Journal: Surg Neurol Int Date: 2018-07-26
Authors: Grant M Fischer; Fernando C L Carapeto; Aron Y Joon; Lauren E Haydu; Huiqin Chen; Fuchenchu Wang; John S Van Arnam; Jennifer L McQuade; Khalida Wani; John M Kirkwood; John F Thompson; Michael T Tetzlaff; Alexander J Lazar; Hussein A Tawbi; Jeffrey E Gershenwald; Richard A Scolyer; Georgina V Long; Michael A Davies Journal: Cancer Med Date: 2020-10-05 Impact factor: 4.452